Anxiolytic Agents Flashcards Preview

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Flashcards in Anxiolytic Agents Deck (22):
1

Antidepressants

1st line agents for most anxiety disorders

NO NDRIs tho

2

Buspirone 5HT


Weaker anxiolytic effect than benzodiazepines, but fewer side effects

3

Benzodiazepines* GABA

Declining use due to abuse potential - used in acute and situational anxiety

4

Barbiturates* GABA

Rarely used for anxiety  low safety margin - drug interactions - high abuse potential

5

Sedative drugs

decrease activity, moderate excitement, and calm the recipient

6

Hypnotic drugs

Produce drowsiness and facilitate the onset and maintenance of sleep

Resembles natural sleep and from which the recipient can be easily aroused

7

5HT drugs

SSRi
SNRi

8

Buspirone

5ht partial

Possible side effects: HA, Lightheadedness, Nervousness, Excitement

May treat: Intellectual disability, Depressive Disorder

9

Sedative - Hypnotic Agents*

Produce graded dose-dependent CNS depressant effects

Distinct mechanism of depressant action: augment GABA inhibition and/or inhibit glutamate excitation

10

Hypnotic drugs

Produce drowsiness and facilitate the onset and maintenance of sleep

Resembles natural sleep and from which the recipient can be easily aroused

11

Sedtavitve hypnotics do

↑ GABA or ↓ Glu

12

Benzos dont work w/o

GABA (at a low dose)

13

Bdz+ gaba-->

↑↑ Cl--> ↓ Em

14

High doses of ETOH and barbs can do?

Open Cl- directly w/o gaba

15

BDZs enhance channel opening only in presence of

GABA

16

_____ prolong channel opening in presence of GABA and at higher doses open channel directly

BARBs

17

Benzos dont do

anesthesia
Can be an additional one though- anastia adjunct

18

Barbs

Can do ana

19

Props

Can do ana

20

GABA- r is

2 alpha
2 beta
1 gama

21

Benzo alone are

safe

bdz + etoh= lethal

22

Drugs for Anxiety

Alprazolam (Xanax®)
Lorazepam (Ativan®)
Clonazepam (Klonopin®)
Diazepam (Valium®)
Busprione (Buspar®)