Know This Antipsychotic Agents Flashcards Preview

Mo-Neuro 4 > Know This Antipsychotic Agents > Flashcards

Flashcards in Know This Antipsychotic Agents Deck (12):
1

↑ DA --> Positive Symptoms

Delusions
Hallucinations
Disordered thoughts

2

↓ DA --> Negative Symptoms

Blunted affect-anhedonia
Alogia - Asociality

3

Effects of Antipsychotic Receptor Block-- Mesolimbic pathway

↓ + symptoms of schizophrenia

4

Mesocortical pathway
Effects of Antipsychotic Receptor Block

↑ - symptoms of schizophrenia

5

Nigrostriatal pathway
Effects of Antipsychotic Receptor Block

↑ Extrapyramidal Side Effects

6

Tuberoinfindibular pathway
Effects of Antipsychotic Receptor Block

Hyperprolactinemia

7

Effects of Antipsychotic Receptor Block
Hypothalamus

Poikilothermia, Weight Gain

8

Chemoreceptor Trigger Zone

Anti-Emetic Effect

9

Acute dystonia (onset 1-5 days)

Torticollis, trismus, opisthotonos

Treatment: anticholinergic agents [diphenhydramine-benztropine]

10

Akathisia (onset 6-60 days)

Motor restlessness – “can’t sit still”

Treatment: reduce dose – change drug – anticholinergic – β blocker, benzodiazepine

11

Pseudoparkinsonism (onset 5-90 days)

Tremor, bradykinesia, rigidity, shuffling gait

Treatment: anticholinergic agents

12

Tardive dyskinesia (onset 3-6 months or longer, 20-40% incidence in elderly females)

D2 receptor supersensitivity?

Involuntary movements of orofacial muscles, choreathetoid movements

Treatment: rarely effective, prevention best strategy