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Flashcards in Know this Insomnia Deck (15):
1

Dose-Response Curves – Barbiturates vs Benzodiazepines

Anterograde amnesia= both

NO anesthesia w/BDZs


2

GABA binds to receptor --> opens Cl channel --> ↓ Em --> ↓ excitability

GABA binds to receptor --> opens Cl channel --> ↓ Em --> ↓ excitability

3

BDZs bind to site on α subunit [α1 and α2-5] intensifying the action of GABA

Presence of GABA required for BDZ effect

4

BARBs bind to distinct site on channel

Low dose: action similar to BDZs

Higher doses: direct interaction with channel – NO GABA required - plus inhibition of excitatory NTs

5

Ethanol

binds both specifically and non-specifically at distinct sites --> action similar to barbiturates

6

"Z”-drugs (structurally distinct from BDZs) bind to same site as BDZs [only _____] - same action

α1

7

Flumazenil - antagonist that binds to same site as BDZs and “Z”-drugs

Used in treatment of benzodiazepine overdose toxicity

NOT effective for BARB or ethanol toxicity

8

BDZs ______________ in presence of GABA only

enhance channel opening

9

BARBs prolong channel opening in presence of GABA and at higher doses open channel ______

directly

10

antagonist that binds to same site as BDZs and “Z”-drugs

Used in treatment of benzodiazepine overdose toxicity

NOT effective for BARB or ethanol toxicity

Flumazenil

11

α1 actions

BDZs
“Z-Drugs”

Sleep
Anticonvulsant*
Amnesia

Additive CNS Depression

12

α2-α5 actions

BDZs

Anxiolytic
Myorelaxant
Motor Incoordination

Tolerance
Dependence
Addiction
↓ REM

13

BDZ Primary Use Insomnia

Flurazepam
Temazapam
Triazolam

14

Primary Anx BDZ

Lorazepam
Alprazolam
Diazepam
to name a few

15

BDZ ↓ N3 and rem after

1 week of use