Anxiolytic-Sedative-Hypnotic Flashcards Preview

Neuro > Anxiolytic-Sedative-Hypnotic > Flashcards

Flashcards in Anxiolytic-Sedative-Hypnotic Deck (15):
1

Phenobarbital

-Long acting barbiturate (less lipid soluble)
-Used for epilepsy, selectively anticonvulsant (other barbs req too high a dose for this)

2

Pentobarbital

-Short-intermediate acting barbiturate

3

Thiopental

-Ultra-short acting barbiturate
-Very lipid soluble
-Can be used as an anesthesia induction drug, usually in dental setting

4

Triazolam

?

5

Flurazepam

-Benzodiazepine
-Plasma half life 2-3 hrs, metabolite >50 hours

6

Alprazolam

?

7

Diazepam

?

8

Lorazepam

?

9

Flumazenil

-Benzodiazepine receptor antagonists
-Reverse effects of benzos, zolpidem, zapelon but not barbs or ethanol

10

Zolpidem (Ambien)

-non-benzodiazepine benzodizepine-receptor agonist AKA z-hypnotics
-Selectively bind to certain subtypes of receptor
-Used for sleep only

11

Ramelteon (Rozerem)

-Agonist at the melatonin MT1 and MT2 receptors located in the brains suprachiasmatic nucleus (SCN) which regulates body's master clock
-Approved for long term use in adults

12

Propranolol (Inderal)

?

13

Melatonin

?

14

What do barbiturates do?

-Reversible depression of all excitable tissue, CNS most sensitive (thru facilitation of GABA-mediated neuronal hyperpolarizatiown
-Goes from mild sedation through anesthesia
-Small doses of barbiturates are HYPERalgesic
-Weak acid
*No tranquilization i.e. doesn't treat anxiety, dose would put them to sleep
*With repeated use, there is a decrease in the drugs therapeutic index

15

What do benzodiazepines do?

-Tranquilization, sedation, hypnosis (not anesthesia)
-Little to no effect outside CNS
-Basically have taken over Barbiturates
-Little drug interactions with high therapeutic index
-When taken with another CNS depressant, can be lethal