Motor Systems: Basal Ganglia Flashcards Preview

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Flashcards in Motor Systems: Basal Ganglia Deck (6)
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1
Q

Hyperkinetic dyskinesia (ballismus due to loss of excitatory drive to GPi). Where is the most likely spot of this lesion?

A

Subthalamic nucleus

2
Q

What happens during Parkinson’s disease; essentially a lesion to substantia nigra pars compacta?

A
  • Bradykinesia
  • Rigidity
  • Rest tremor of 4-7 Hz
  • Postural instability
3
Q

Where is the most likely spot of a lesion resulting in:

  • flexion dystonia/flexion posturing
  • Dystonia/rigidity representing an increase in motor activity
A

Globus pallidus. Loss of normal tonic inhibitory activity of GPi on VA/VL of thalamus.

4
Q

What striatal lesion results in a more complex behavior disorders such as:

  • vulgarity, impulsiveness
  • Increased appetite, polydipsia
  • Hypersexuality
A

Caudate

5
Q

What striatal lesion is more motoric in nature, affecting stereotypic behavior?

A

Putamen

6
Q

What is the pathology and symptoms of Huntingtons disease?

A

Initially death of spiny neurons in neostriatum (particularly GABA/ENK group), resulting in chorea. All of striatum eventually dies. Develop akinesia as direct pathway is affected.