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Flashcards in April 10 Deck (9)
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1

What are features of chronic bronchitis?

Thickened bronchial walls
Lymphocytic infiltration
Mucous gland enlargement --increased goblet cells
Squamous cell metaplasia

Cigarette smoking is the leading cause

2

What is the cause of tetralogy of fallot?

Due to deviation of infundibular septum
--most common cause of early childhood cyanosis
--squatting: increases SVR, decreases right-to-left shunt--improves cyanosis

3

What inherited disorder is caused by deficient DNA repair enzymes and is characterized by DNA hypersensitivity to ionizing radiation?

Ataxia-telangiectasia

4

Disorder of the inner ear characterized by increased volume and pressure of endolymph due to defective resorption?

Meniere disease --causes damage to vestibular and cochlear components of the inner ear

Triad:
-Low frequency tinnitus
-Vertigo
-Sensorineural hearing loss

5

What is the 1st line tx for OCD?

SSRI
--Target is 5-HT

6

What is the major immune mechanism against Giardia?

CD4+ T helper cells and secretory IgA production---impairs adherence to the small bowel mucosa

7

How do ACE inhibitors cause an increased Cr shortly after being started?

Blockage of Angiotensin II action on the efferent arteriole causes vasodilation of the arteriole--decreasing GFR and increasing CR.

Angiotensin II normally vasoconstricts the efferent

8

What NSAID does NOT impair platelet function?

COX-2 selective Celecoxib

9

What is the MOA of Bupropion used as antidepressant and what is its most severe side effect?

Increase NE and DA

Seizures can be seen in anorexic/bulimic pts

Also used for smoking cessation