Flashcards in April 15 Deck (40)
What embryologic structure forms the glomerulus through to distal convoluted tubule?
Metanephric mesenchyme (metanephric blastema)
What embryologic structure forms the ureter, pelvises, calyces, collecting ducts?
Metanephric diverticulum--Ureteric bud
What process provides a source of NADPH, occurs within the cytoplasm and what enzymes are used in this process?
HMP shunt--pentose phosphate pathway
Glucose-6-phosphate dehydrogenase and transketolase
Pt with DKA is going to have increased excretion of what 2 substance in the urine and what will decrease with the urine?
Increased NH4+ and H2PO4- --increased H+ secretion
Decreased pH and HCO3- excretion---bicarb will be resorbed at increased rate
Damage to the infraorbital nerve due to fracture of the orbital floor, which is composed of the zygomatic bone and maxilla, will cause what symptoms?
Numbness and paresthesia to the upper check, upper lip, and upper gingiva
Displacement of the orbital contents through the floor may cause enophthalmos, entrapment of the inferior rectus muscle impairing superior gaze.
Disorder involving recurrent unexpected panic attacks characterized by an abrupt surge of fear accompanied by physical and cognitive symptoms?
Pt continuously worries about future attacks and restricts activity as a result
Pt received inject and shortly after walked with a limb where is right hip would drop when he lifted his right foot off the ground. Where was the shot administered?
Left superomedial quadrant of the buttock
Where does Isotyping of B-cells occur and what is required?
Germinal centers of lymph nodes
--requires interaction of CD40 with CD40L (CD154) expressed by activated T-cells
Pt presents with unilateral JVD and has lung cancer. Dx?
Right side Brachiocephalic vein obstruction--causing back-up into Jugular
What is the MOA of rasburicase and what is it used for?
Recombinant fricassee that catalyzes metabolism of uric acid to allantoin
Used for prevention and tx of tumor lysis syndrome--oncologic emergency that den develop from chemo causing rapid breakdown of cancer cells and high cell turnover
PE is associated with hypoxemia and ______ alkalosis.
What is the most important mediator of Giant cell (temporal) arteritis?
Production of IL-6 cytokine--cell mediated immunity
Epidermal accumulation of edematous fluid in intercellular spaces--seen with eczematous dermatitis?
Collects data from group of people to assess frequency of disease at a particular point in time--What is happening at that point in time?
Phenylalanine is a derivative of what?
Tryptophan is a derivative of what?
Histidine is a derivative of what?
Glycine is a derivative of what?
Glutamate is a derivative of what?
Arginine is a derivative of what?
What is essential in a pts diet who has homocystinuria and how does it present?
Commonly caused by cystathionine synthase deficiency which makes it cysteine is unable to be synthesized from homocysteine
Homocysteine builds up causing increased methionine
--prothrombotic causing premature thromboembolic events such as MI in young pt (like 12 y/o)
Trypsinogen is activated to trypsin by ________.
--trypsin is essential for protein digestion and absorption
Injury to the supraspinatus muscle results in pain during what type of motion?
Abduction of the arm
What is the most reliable auscultatory finding indicating a high regurgitant volume and LV volume overload seen with mitral regurgitation?
Left sided S3 gallop
Holosystolic, high-pitched "blowing murmur"--loadest at apex and radiates toward axilla
What nerve innervates the extensors of the hand?
What drug is used with pheochromocytoma to irreversibly inhibit a1 and a2?
Phenoxybenzamine--blocks action of NE
--reduces the arterial vasoconstriction caused by NE
Med used for DM2 that increases insulin sensitivity in peripheral tissue?
-Pioglitazone and rosiglitazone
Binds to PPAR-g nuclear transcription regulator
--decreases insulin resistance
What is the function of c-MYC?
Transcription factor ---transcription activator controlling cell proliferation, differentiation, and apoptosis
8;14 translocation seen with Burkitt lymphoma
What is the MOA of etanercept?
EtanerCEPT is a TNF decoy reCEPTor