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Flashcards in April 29 Deck (13)
1

What is the function of prostacyclin--PGI2?

Increased vascular permeability
Vasodilates
Inhibits platelet aggregation

Works opposite of thromboxane--work together to keep vascular homeostasis

2

What is the cause of Dubin-Johnson syndrome and what causes the liver to become black?

Defective hepatic excretion of bilirubin glucuronides across canalicular membrane

Black liver--Impaired excretion of epinephrine metabolites

3

Anti-smith antibodies seen in SLE are antibodies against what?

Autoantibodies directed against snRNPs--which are essential components of spliceosomes, which remove introns from pre-mRNA to form mature mRNA

4

What is used to control the symptoms of delirium--agitation and psychosis?

High-potency 1st gen anti-pshycotics --Haloperidol

5

What drugs cause decreased production of aqueous humor by the ciliary epithelium in the eye?

Timolol
Acetazolamide
a2-agonists

6

What drugs increase the outflow of aqueous humor through the trabecular meshwork?

Prostaglandin F2a--Latanoprost and travoprost
Cholinomimetics--pilocarpine, carbachol

7

What mediates calcium efflux from cardiac cells prior to relaxation?

Na/Ca exchanger and SR--Ca ATPase (SRCA)
--reuptake of calcium

8

What are the symptoms of DRESS syndrome and what drugs can cause it?

Fever
Generalized lymphadenopathy
Facial edema
Diffuse skin rash
Eosinophilia
Internal organ dysfunction

Occurs 2-8 wks after introduction to --anticonvulsants, allopurinol, sulfonamides, antibiotics (vanco and minocycline)

9

What causes an isolated increase in bleeding time and is caused by platelet dysfunction?

Uremic platelet dysfunction seen in pts with renal failure

10

1st infection with dengue fever is different compared to 2nd how?

1st infection usually milder symptoms that resolve, but 2nd infection is usually by different viral serotype and causes a more severe illness

11

Pancytopenia with absence of splenomegaly is most indicative of what?

Aplastic anemia

12

Mid systolic click murmur that disappears with squatting is indicative of what?

Mitral valve prolapse --connective tissue defect

13

Leukocyte alkaline phosphatase is decreased in what disease?

CML

Normal or increased with leukemoid reaction