Flashcards in April 29 Deck (13)
What is the function of prostacyclin--PGI2?
Increased vascular permeability
Inhibits platelet aggregation
Works opposite of thromboxane--work together to keep vascular homeostasis
What is the cause of Dubin-Johnson syndrome and what causes the liver to become black?
Defective hepatic excretion of bilirubin glucuronides across canalicular membrane
Black liver--Impaired excretion of epinephrine metabolites
Anti-smith antibodies seen in SLE are antibodies against what?
Autoantibodies directed against snRNPs--which are essential components of spliceosomes, which remove introns from pre-mRNA to form mature mRNA
What is used to control the symptoms of delirium--agitation and psychosis?
High-potency 1st gen anti-pshycotics --Haloperidol
What drugs cause decreased production of aqueous humor by the ciliary epithelium in the eye?
What drugs increase the outflow of aqueous humor through the trabecular meshwork?
Prostaglandin F2a--Latanoprost and travoprost
What mediates calcium efflux from cardiac cells prior to relaxation?
Na/Ca exchanger and SR--Ca ATPase (SRCA)
--reuptake of calcium
What are the symptoms of DRESS syndrome and what drugs can cause it?
Diffuse skin rash
Internal organ dysfunction
Occurs 2-8 wks after introduction to --anticonvulsants, allopurinol, sulfonamides, antibiotics (vanco and minocycline)
What causes an isolated increase in bleeding time and is caused by platelet dysfunction?
Uremic platelet dysfunction seen in pts with renal failure
1st infection with dengue fever is different compared to 2nd how?
1st infection usually milder symptoms that resolve, but 2nd infection is usually by different viral serotype and causes a more severe illness
Pancytopenia with absence of splenomegaly is most indicative of what?
Mid systolic click murmur that disappears with squatting is indicative of what?
Mitral valve prolapse --connective tissue defect