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Flashcards in Autoimmune Hepatitis Deck (6)
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1

What is autoimmune hepatitis.

It consists of periportal piecemeal necrosis/bridging necrosis, and fibrosis.

It is a disease of immune-mediated liver injury characterized by the presence of serum antibodies and peripheral blood T lymphocytes reactive with self-proteins.
It has a strong association with other autoimmune diseases.

2

What is the serum immunoglobulin most commonly raised in autoimmune hepatitis.

IgG.

3

Who is autoimmune hepatitis seen in.

Most commonly seen in women.
However, it can occur in any sex at any age.
Acute presentations usually occur in teens - 30s.
Chronic presentations can occur at any point, but are more common in women over 40.

4

What are the symptoms of autoimmune hepatitis. (9)

The onset of symptoms is usually insidious:
Fatigue.
Abdominal discomfort.
Decreased appetite.
Myalgia.
Jaundice.

In about 1/4 of patients, the onset is acute:
Fever.
Arthralgia.
Vitiligo.
Epistaxis.
Amenorrhoea can occur.

5

What are the signs of autoimmune hepatitis. (3)

Hepatomegaly.
Icterus.
Signs of chronic liver disease/cirrhosis.
Jaundice is mild to moderate.
Associated autoimmune disease (eg Hashimoto's thyroiditis or rheumatoid arthritis) may be present in acute presentations.
Other signs of autoimmune disease are present in acute presentations:
Urticarial rash.
Polyarthritis.
Pleurisy,
Pulmonary infiltrations.
Glomerulonephritis.

6

What conditions are associated with autoimmune hepatitis. (12)

Migrating polyarthritis.
Urticarial rashes.
Lymphadenopathy.
Hashimoto's thyroiditis.
Thyrotoxicosis.
Myxoedema.
Pleurisy.
Coombs-positive haemolytic anaemia.
Transient pulmonary infiltrates.
Ulcerative colitis.
Glomerulonephritis.
Nephrotic syndrome.