Flashcards in Autoimmune Hepatitis Deck (6)
What is autoimmune hepatitis.
It consists of periportal piecemeal necrosis/bridging necrosis, and fibrosis.
It is a disease of immune-mediated liver injury characterized by the presence of serum antibodies and peripheral blood T lymphocytes reactive with self-proteins.
It has a strong association with other autoimmune diseases.
What is the serum immunoglobulin most commonly raised in autoimmune hepatitis.
Who is autoimmune hepatitis seen in.
Most commonly seen in women.
However, it can occur in any sex at any age.
Acute presentations usually occur in teens - 30s.
Chronic presentations can occur at any point, but are more common in women over 40.
What are the symptoms of autoimmune hepatitis. (9)
The onset of symptoms is usually insidious:
In about 1/4 of patients, the onset is acute:
Amenorrhoea can occur.
What are the signs of autoimmune hepatitis. (3)
Signs of chronic liver disease/cirrhosis.
Jaundice is mild to moderate.
Associated autoimmune disease (eg Hashimoto's thyroiditis or rheumatoid arthritis) may be present in acute presentations.
Other signs of autoimmune disease are present in acute presentations: