Autoimmune Insulin Dependent Diabetes Flashcards Preview

Jonathan's Metabolism > Autoimmune Insulin Dependent Diabetes > Flashcards

Flashcards in Autoimmune Insulin Dependent Diabetes Deck (10):
1

How can we diagnose autoimmune disease with drugs?

Use immunosuppressive drugs. If the symptoms improve, then it is autoummune

2

When is the best time to treat diabetes type I

during the pre-clinical period, where there is immunologic abnormalities but normal insulin release. However, not many people are diagnosed at this stage

3

T/F Risk of type I diabetes is already high with one autoantibody

False, but it goes up significantly with two autoantibodies

4

What does a type I diabetes pancreas look like under the microscope/histology?

lymphocyte infiltration
reduced staining for insulin
normal islet hormone secretion
only beta cells are affected

5

Which cell causes the most damage to insulin beta cells in diabetes

CD8+ cells with perforin and granzymes

6

What is AIRE gene important for?

central tolerance

7

What is FOXP3 gene important for?

Treg cells

8

What are the MLC haplotypes linked to type 1 diabetes?

HLA-DR3, DR4, DQ8

9

Which region does the T cells recognise on the beta cell?

the C-peptide region in the context of DQ8

10

What is the disadvantage of using insulin as a treatment for diabetes?

incapable to mimic physiological glucose control
uniquely burdensome