Flashcards in Autoimmune Insulin Dependent Diabetes Deck (10):
How can we diagnose autoimmune disease with drugs?
Use immunosuppressive drugs. If the symptoms improve, then it is autoummune
When is the best time to treat diabetes type I
during the pre-clinical period, where there is immunologic abnormalities but normal insulin release. However, not many people are diagnosed at this stage
T/F Risk of type I diabetes is already high with one autoantibody
False, but it goes up significantly with two autoantibodies
What does a type I diabetes pancreas look like under the microscope/histology?
reduced staining for insulin
normal islet hormone secretion
only beta cells are affected
Which cell causes the most damage to insulin beta cells in diabetes
CD8+ cells with perforin and granzymes
What is AIRE gene important for?
What is FOXP3 gene important for?
What are the MLC haplotypes linked to type 1 diabetes?
HLA-DR3, DR4, DQ8
Which region does the T cells recognise on the beta cell?
the C-peptide region in the context of DQ8