Flashcards in Oral Hypoglycaemics Deck (12):
What is an example of Sulfonylurea
What is the action of sulfonyurea?
increase insulin secretion from B cells, in phase 1 spike
What is the mechanism of action of sulfonyurea?
inhibit K(ATP) channels
What is the action of Metformin?
Increase insulin sensitivity - increase glucose uptake, reduce glucose production, decrease carb absorption, reduce LDL level
What is the side effect of metformin?
GI disturbances, diarrhoea, nasea, anorexia
What is the contraindication of metformin?
Impaired renal function
What is Thiazolidinediones similar to?
What is the action of acarbose?
it's an alpha-glucosidase inhibitor, reduce starch absorption
What is the adverse effect of acarbose?
loose stools and abdo pain
What is the contraindication of acarbose?
inflammatory bowel disease or cirrhosis
What is the action of gliptin
increase native GLP-1 levels to increase insulin and decrease glucagon