Oral Hypoglycaemics Flashcards Preview

Jonathan's Metabolism > Oral Hypoglycaemics > Flashcards

Flashcards in Oral Hypoglycaemics Deck (12):
1

What is an example of Sulfonylurea

Chlorpropramide

2

What is the action of sulfonyurea?

increase insulin secretion from B cells, in phase 1 spike

3

What is the mechanism of action of sulfonyurea?

inhibit K(ATP) channels

4

What is the action of Metformin?

Increase insulin sensitivity - increase glucose uptake, reduce glucose production, decrease carb absorption, reduce LDL level

5

What is the side effect of metformin?

GI disturbances, diarrhoea, nasea, anorexia

6

What is the contraindication of metformin?

Impaired renal function

7

What is Thiazolidinediones similar to?

BIguanides (metformin)

8

What is the action of acarbose?

it's an alpha-glucosidase inhibitor, reduce starch absorption

9

What is the adverse effect of acarbose?

flatulence/abdo discomfort
loose stools and abdo pain

10

What is the contraindication of acarbose?

inflammatory bowel disease or cirrhosis

11

What is the action of gliptin

increase native GLP-1 levels to increase insulin and decrease glucagon

12

What is the action of Exenatide?

incretin mimetics and enhancers, regulating glucagon and insulin