Flashcards in Mitochondria Deck (19):
T/F mitochondria are all maternally derived
True, sperm mitochondria are discarded at fertilisation
Which molecule is the hallmark of mitochondrial disease?
ragged red fibres
What are the three major pathway for making ATP
glycolysis to make pyruvate/acetyl-CoA
citric acid cycle to make NADH and FADH2
respiratory chain to make final ATP
what is the use of carnitine
it is a channel that allows fatty acid to enter the mitochondrial matrix
T/F Urea cycle occurs in the cytoplasm
True, but the initiation process occurs in the mitochondria
Where the citric acid cycle take place in a cell
mitochondria matrix. Pyruvate needs to get transported into the matrix
What is the product of citric acid cycle
Where are the enzymes for electron transport chain located?
the inner mitochondrial membrane, separating intermembrane space and matrix
How does cyanide kill you?
it stops cytochrome involved in respiratory chain
What's the function of enzyme Q10
Carries electron laterally in the electron transport chain
WHen will membrane ATP synthase become an ATPase
when the mitochondrial membrane is broken
How many hydrogens are pumped into intermembrane space during electron transport chain?
Which part of the electron transport complex requires copper
What is proton motive force and how is it generated?
It is using the movement of proton down its gradient to generate ATP
NADH provides the energy to pump out H+ ions and create the gradient
Where is the oxidative damage to mitochondria coming from?
When electrons are carried by enzyme Q, there may be leakage of electrons, forming RoS
Can protons leak through the inner membrane without ATP synthase?
Yes, this uncoupling leak generates heat
How many ATPs are generated per electron transport chain cycle?
What's the function of malate-aspartate shuttle?
It transfers the reducing power of NADH from cytosol into the mitochondria for oxidative phosphorylation