Mitochondria Flashcards Preview

Jonathan's Metabolism > Mitochondria > Flashcards

Flashcards in Mitochondria Deck (19):
1

T/F mitochondria are all maternally derived

True, sperm mitochondria are discarded at fertilisation

2

Which molecule is the hallmark of mitochondrial disease?

ragged red fibres

3

What are the three major pathway for making ATP

glycolysis to make pyruvate/acetyl-CoA
citric acid cycle to make NADH and FADH2
respiratory chain to make final ATP

4

what is the use of carnitine

it is a channel that allows fatty acid to enter the mitochondrial matrix

5

T/F Urea cycle occurs in the cytoplasm

True, but the initiation process occurs in the mitochondria

6

Where the citric acid cycle take place in a cell

mitochondria matrix. Pyruvate needs to get transported into the matrix

7

What is the product of citric acid cycle

3x NADH
1x FADH2
1x GTP

8

Where are the enzymes for electron transport chain located?

the inner mitochondrial membrane, separating intermembrane space and matrix

9

How does cyanide kill you?

it stops cytochrome involved in respiratory chain

10

What's the function of enzyme Q10

Carries electron laterally in the electron transport chain

11

WHen will membrane ATP synthase become an ATPase

when the mitochondrial membrane is broken

12

How many hydrogens are pumped into intermembrane space during electron transport chain?

10

13

Which part of the electron transport complex requires copper

complex 4

14

What is proton motive force and how is it generated?

It is using the movement of proton down its gradient to generate ATP

NADH provides the energy to pump out H+ ions and create the gradient

15

Where is the oxidative damage to mitochondria coming from?

When electrons are carried by enzyme Q, there may be leakage of electrons, forming RoS

16

Can protons leak through the inner membrane without ATP synthase?

Yes, this uncoupling leak generates heat

17

How many ATPs are generated per electron transport chain cycle?

32

18

What's the function of malate-aspartate shuttle?

It transfers the reducing power of NADH from cytosol into the mitochondria for oxidative phosphorylation

19

T/F Glycerol-3-phosphate is more energy expensive, but operates rapidly

True