Autonomic Pharmacology Flashcards Preview

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Flashcards in Autonomic Pharmacology Deck (138)
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1

Symptoms of excess parasympathetic activity?

Diarrhea
Urinary retention
Miosis / ciliary muscle contraction
Bradycardia
BronchoSPASM
Excitation (muscles and CNS)
Lacrimation
Salivation
Sweating

2

Parasympathetic inhibition is aka ______ or ______ inhibition. Symptoms of parasympathetic inhibition?

Parasympathetic = muscarinic inhib, or anti-cholinergic. Sx =
Hot as a hare
Dry as a bone
Red as a beet
Blind as a bat (cycloplegia, mydriasis)
Mad as a hatter
Bloated as a toad (urinary retention & constipation)

3

Effect of anti-muscarinics on heart rate?

Inhibition of vagal tone = tachycardia

4

Three anti-muscarinic drugs used topically for pupillary dilation:

Homatropine
Tropicamide
Cyclopent.

5

Atropine is used mainly for (2):

Treatment of bradycardia
As an antidote to organophosphate poisoning (organophosphates inhibit AChE, too much ACh, need to switch parasympathetics off).

6

This drug is helpful in Parkinson's and in tx of EPS from antipsychotic use:

Benztropine

7

Antimuscarinic used in tx of motion sickness:

Scopolamine

8

Antimuscarinic for COPD and asthma (2):

Ipratropium
Tiotropium

9

Antimuscarinics used to help increase urinary retention in urge incontinence (5):

Oxybutynin
Tolterodine
Darifenacin
Solifenacin
Trospium

10

This antimuscarinic drug helps decrease oral secretions in intubated patients. What is its other main use?

Scopolamine
Also used for motion sickness

11

This drug helps decrease oral secretions when given parenterally:

Glycopyrrolate

12

Physostigmine: Direct cholinergic agonist, anticholinesterase, or anti-muscarinic?

Anti-cholinesterase

13

Pilocarpine: Direct cholinergic agonist, anticholinesterase, or anti-muscarinic?

Direct cholinergic agonist

14

Oxybutynin: Direct cholinergic agonist, anticholinesterase, or anti-muscarinic?

Anti-muscarinic

15

Atropine: Direct cholinergic agonist, anticholinesterase, or anti-muscarinic?

Direct cholinergic agonist

16

Donepezil: Direct cholinergic agonist, anticholinesterase, or anti-muscarinic?

Anti-cholinesterase

17

Pralidoxime: Direct cholinergic agonist, anticholinesterase, or anti-muscarinic?

Trick question!
Cholinesterase RE-GENERATOR.

18

Bethanecol: Direct cholinergic agonist, anticholinesterase, or anti-muscarinic?

Direct cholinergic agonist

19

Neostigmine: Direct cholinergic agonist, anticholinesterase, or anti-muscarinic?

Anti-cholinesterase

20

Darifenacin: Direct cholinergic agonist, anticholinesterase, or anti-muscarinic?

Anti-muscarinic

21

Ipratropium: Direct cholinergic agonist, anticholinesterase, or anti-muscarinic?

Anti-muscarinic

22

Tropicamide: Direct cholinergic agonist, anticholinesterase, or anti-muscarinic?

Anti-muscarinic

23

Benztropine: Direct cholinergic agonist, anticholinesterase, or anti-muscarinic?

Anti-muscarinic

24

Scopolamine: Direct cholinergic agonist, anticholinesterase, or anti-muscarinic?

Anti-muscarinic

25

Edrophonium: Direct cholinergic agonist, anticholinesterase, or anti-muscarinic?

Anti-cholinesterase

26

Tolterodine: Direct cholinergic agonist, anticholinesterase, or anti-muscarinic?

Anti-muscarinic

27

Trospium: Direct cholinergic agonist, anticholinesterase, or anti-muscarinic?

Anti-muscarinic

28

Rivastigmine: Direct cholinergic agonist, anticholinesterase, or anti-muscarinic?

Anti-cholinesterase

29

Homatropine: Direct cholinergic agonist, anticholinesterase, or anti-muscarinic?

Anti-muscarinic

30

Pyridostigmine: Direct cholinergic agonist, anticholinesterase, or anti-muscarinic?

Anti-cholinesterase