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Flashcards in Immunology Deck (181)
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1

Primary lymphoid organs (2):

Thymus
Bone marrow

2

Site of B cell localization in a lymph node:

Follicle

3

Where the T cells in a lymph node are located:

Paracortex
(This is right next to the follicle)

4

Portion of a lymph node that becomes hugely enlarged in a robust cellular immune response:

Paracortex

5

Why do lymph nodes not enlarge in patients with DiGeorge?

They have no T cells. The paracortex, or T cell region, is what enlarges when a lymph node swells.

6

Where are the high endothelial venules of lymph nodes located?

Paracortex
T and B cells enter here

7

The primary lymph node drainage site for the upper limb and lateral breast:

Axillary

8

The primary lymph node drainage site for the stomach:

Celiac nodes

9

The primary lymph node drainage site for the duodenum and jejunum:

Superior mesenteric nodes

10

The primary lymph node drainage site for the sigmoid colon:

Colic nodes, which drain to inferior mesenteric nodes

11

The primary lymph node drainage site for the rectum above the pectinate line:

Internal iliac nodes

12

The primary lymph node drainage site for the anal canal below the pectinate line:

Superficial inguinal nodes

13

The primary lymph node drainage site for the testes:

Superficial and deep para-aortic plexes

14

The primary lymph node drainage site for the scrotum:

Superficial inguinal nodes

15

What does the right lymphatic duct drain? What happens if you obstruct this duct or it gets damaged?

The right arm, chest, and right half of the head.
Damage -> non-pitting edema of RUE.

16

Where does the thoracic duct empty?

Jx of L subclavian and IJ

17

Three ways you can become asplenic:

Sickle cell
Trauma
Surgery (eg for spherocytosis)

18

Where are T cells in the spleen?

They live in the peri-arteriolar lymphatic sheath (PALS).
Remember, P for Paracortex (LN) and PALS (spleen).

19

Where are B cells found in the spleen?

In the follicles in the white pulp.

20

T/F: T cells are found in the red pulp of the spleen.

F. PALS is where they live, this is in the white pulp.

21

Post-splenectomy, 3 buzzwords:

Howell-Jolly bodies
Target cells
Thrombocytosis

22

Asplenia renders someone vulnerable to what organisms? Which do we have vaccines for?

Encapsulated ones. Even Some Killers Have Pretty Nice Capsules:
E. coli
Strep pneumo *
Klebsiella
H. influenzae *
Pseudomonas
Neisseria (mening. and gonococcal *)
Cryptococcus

23

From what embryonic structure does the thymus come? What other structure develops from this origin?

The 3rd branchial pouch. Inferior parathyroids develop with the thymus.

24

In the thymus, where do mature T cells live? What kind of selection are they undergoing here?

Mature T cells live in the Medulla of the thymus, here they are undergoing (-) selection (learning not to kill the host cells).

25

In the thymus, where do immature T cells live? What kind of selection are they going through here?

Immature T cells live in the cortex.
Mature live in the Medulla.
They are undergoing (+) selection and learning to talk MHC.

26

The HLA subtypes associated with MHC I:

HLA-A
HLA-B
HLA-C

27

To what co-receptor does MHC I bind? MHC II?

CD8
CD4

28

Which cells express MHC I?
Which cells express MHC II?

MHC I is on the surface of all nucleated cells.
MHC II is only on APCs (macs, B cells, dendritic cells).

29

Which HLA subtypes are associated with MHC II?

Dr. is going to DQ to get a DrPepper.
HLA-DR
HLA-DQ
HLA-DP

30

Which MHC molecule needs to travel with b2 microglobulin to be displayed?

MHC I