Flashcards in Endocrine Deck (138)
Which endocrine hormones are IP3 linked? T/F: Hormones from the posterior pituitary are IP3-linked.
GGOAT "butts" you:
Oxytocin / ADH are from the posterior pituitary and are IP3-linked.
Which endocrine hormones are cAMP linked? (12)
calcitonin / GHRH / glucagon too!
Hormones in the anterior pitiutary tend to be linked to which signaling pathway? Can you name 4?
cAMP. These include FSH, LH, ACTH, TSH.
Endocrine hormones which signal through steroid receptors (6):
Vitamin D, Estrogen, Testosterone, T3/T4, Cortisol, Aldosterone, Progesterone
Effect of too much SHBG in men? Too little in women?
Men: Gynecomastia with high SHBG.
Women: Hirsutism with low SHBG.
What kind of signaling path does prolactin use?
What kind of signaling path does oxytocin use?
What signaling path does insulin use?
GH is secreted from:
Glucocorticoids are secreted from:
The adrenal cortex, zona fasciculata
Progesterone is secreted from (2):
Prolactin comes from the:
Oxytocin comes from the:
Glucagon comes from the:
Insulin comes from:
Somatostatin comes from:
Glucagon from alpha cells of pancreas
Insulin from beta cells
Somatostatin from delta cells
FSH comes from the:
Vasopressin (ADH) comes from:
The hypothalamus (supraoptic nucleus), is stored in the posterior pituitary
TSH comes from the:
Estradiol comes from the:
Estriol comes from the:
Estrone is made by:
Lutenizing hormone comes from the:
Mineralocorticoids / aldosterone comes from the:
Zona glomerulosa of the adrenal cortex
ACTH is excreted by the:
This molecule is the precursor to ACTH, lipotropins, MSH, and the beta-endorphins:
Four main causes of hyperprolactinemia:
1. Pregnancy / nipple stimulation
4. Dopamine antagonists
Where is somatostatin made?
In the GI tract, mostly D cells in gut mucosa, pancreatic delta cells make it too.
What does somatostatin do?
Inhibits secretion of GI hormones, decreases endocrine / exocrine secretion, reduces GI motility and GB contraction.
Three somatostatin analogues that are used clinically:
In the fetus, this hormone is secreted late in gestation and is responsible for lung maturation: