Autonomics Flashcards Preview

STEP 1 Pharm > Autonomics > Flashcards

Flashcards in Autonomics Deck (38):
1

Hemicholinium

Blocks transport of choline into neurons. No acetylcholine synthesis

2

Vesimacol

Prevents loading of Ach into vesicles

3

Botulinum

Blocks release of Ach vesicles

4

Metyrosine

Blocks conversion of tyrosine to dopa

5

Reserpine

Blocks packaging of dopamine into vesicles

6

Bethanecol

Muscarinic agonist that moves bowel and bladder. Used for postop ileus and urinary retention

7

Carbachol

Used for glaucoma and relief of intraocular pressure.

8

Pilocarpine

Used for glaucoma. Stimulates sweat, tears, soliva

9

Methacholine

Used to bronchoconstrict for asthma tests

10

Neostigmine

ACHe inhibitor used to reverse neuromuscular blockade. Also used in myesthenia gravis. NO CNS penetration

11

Physostigmine

Penetrates CNS, used in atropine poisoning.

12

Pyridostigmune

used for myesthenia gravis

13

Donepezil, rivastigmine, galantamine

Ache inhibitors used to increase cognitive ability

14

Edrophonium

Short lasting ache inhibitor used to diagnose MG

15

Cholinesterase inhibitor poisoning

Organophosphates irreversibly inhibit ACHE. Causes bradycardia, bronchoconstriction, diarrhea, lacrimation, unination, miosis, salivation.

Treat with atropine and pralidoxime.

Poisoning usually seen in farmers.

16

Atropine

Muscarinic antagonist used for the eye. Causes mydriasis and cycloplegia

17

Benztropine

Antimuscarinic used for PD

18

Scopolamine

Antimuscarinic used for motion sickness

19

Ipratropium/tiotropium

Used for asthma/COPD

20

Oxybutynin/darifenacin/solifenacin

Used to reduce urgency in cystitis

21

Glycopyrollate

Preoperative use to reduce airway secretions. Also used in peptic ulcers

22

Epinephrine

Beta>alpha.

23

Norepinephrine

a1>a2>b

24

Isoproterenol

B1=b2 agonist

25

Dopamine

D1=D2>b>a.

26

Dobutamine

B1>b2=a. Used for heart failure. Has inotropic effects.

27

Phenylephrine

A1>a2

28

Albuterol

B2>b1

29

Treat cocaine intoxication with beta blockers?

NO WAY! unopposed alpha effects can lead to extreme hypertension

30

A2 agonists

Clonidine = used for hypertensive urgency, also ADHD and severe pain

Methyldopa - used to treat hypertension in pregnancy

31

Methyldopa side effects

Coombs positive hemolytic anemia, SLE like syndrome

32

Nonselective Alpha blockers

Phenoxybenzamine (irreversible)- used to treat pheochromocytoma
Phentolamine (reversible) - used in tyramine crisis

33

A1 selective alpha blockers

Prazosin, tamulosin, doxazosin. Used to treat the urinary symptoms of bph (relax bladder). Prazosin also used to treat PTSD.

Can cause first dose hypertension, dizziness, headache

34

A2 blocker

Mirtazepine used for depression

Sedation, increased serum cholesterol, increased appetite

35

B1 selective antagonists

Acebutolol, betaxolol, carvedilol, esmolol, atenolol

36

Non selective beta antagonists

Nadolol, pindolol, propanolol, timolol

37

Nonselective alpha and beta antagonists

Carvedilol, labetalol

38

Toxicity of beta blockers

Impotence, sedation, depression, dyslipidemia (metoprolol). CAN use in diabetics regardless of theoretical risks.