Flashcards in Respiratory Deck (20):
First generation antihistamines
Diphenhydramine, dimenhydrinate, chlorpheniramine.
Used for allergy, motion sickness, as a sleep aid.
First generation antihistamine toxicity
Sedating -- crosses BBB
Antimuscarinic and anti alpha adrenergic effects
Causes urinary retention, dry mouth, delirium)
Second generation antihistamines
Fexofenidine, cetirizine, desloratidine, loratidine
Used for allergy
Less CNS penetration
Expectorant that thins secretions but does not suppress gag reflex
Mucolytic -- breaks SH bonds to break up mucous
Antitussive (NMDA receptor antagonist) codeine analog. Treat with naloxone
Alpha agonist nasal decongestant
Pseudoephedrine side effects
CNS stimulation/anxiety and hypertension
B agonist that activates b2 which relaxes smooth muscle in airway
Long acting B agonists that are used for asthma prophylaxis.
Salmeterol/formoterol side effects
Tremor and arrhythmia
Phosphodiesterase inhibitor that increases cAMP in bronchial smooth muscle.
Narrow therapeutic range, metabolized by cyp450, can cause seizures. Blocks actions of adenosine
M3 blocker (competitive) that prevents bronchoconstriction. Also used for COPD as tiotropium
Inhibit synthesis of cytokines by inactivating NFKB (the transcription factor that induces TNF alpha). First line therapy for chronic asthma.
Antileukotriene drugs side effect
Montelukast/zafirlucast. Can increase liver enzymes.
Monoclonal anti-ige antibody that binds unbound IgE and prevents binding to receptors on mast cells. used for asthma resistant to inhaled steroids and long acting beta two agonists
used to challenge, drop in fev 1 more than 20 percent means asthma
Endothelin receptor antagonist to decrease pulmonary hypertension