Flashcards in Repro drugs Deck (22):
GnRH analog with agonist properties when used in pulsatile fashion. Antagonist when used continuously. Downregulates GnRH receptor in pituitary and decreases FSH and LH.
Used for prostate cancer, uterine fibroids, precocious puberty
ethinyl estradiol, DES, mestranol.
Bind estrogen receptors. Used for hypogonadism or ovarian failure, menstrual abnormalities, HRT in postmenopausal women.
Increased risk of endometrial cancer. Can cause clear cell carcinoma in babies exposed to DES. Increased risk of thrombi.
Don't use in ER+ breast cancer or with history of DVT
A SERM. Antagonist at estrogen receptors in hypothalamus, so prevents normal feedback, increasing LH and FSH from pituitary which stimulates ovulation. Used to treat infertility due to PCOS and other anovulatory conditions.
Hot flashes, ovarian enlargement, multiple simultaneous pregnancies, visual disturbances
A SERM. Antagonist of estrogen at breast tissue. Agonist at uterus and bone.
Can increase risk of endometrial cancer and thromboembolism
A serm, agonist on bone, antagonist at uterus.
Aromatase inhibitor used in postmenopausal women with breast cancer.
Bind progesterone receptors, decrease growth and increase vascularization of endometrium. Used as oral contraceptives and in the treatment of endometrial cancer and AUB.
An inhibitor of progestins at progesterone receptors. Used to terminate pregnancy, adminstered with misoprostol
How does oral contraception work?
Estrogen and progestins inhibit LH and FH and therefore decrease estrogen surve. No LH surge and no ovulation.
Progestins cause thickening of cervial mucus and limit access of sperm.
Contraindications for oral contraception
Smokers >35 years old -- can cause cardiovascular events
patients with history of stroke
B2 agonist that is used to relax the uterus. Used to reduce contraction frequency in women during labot
Synthetic androgen that act as a partial agonist at androgen receptors. used for endometriosis and angioedema.
Weight gain, edema, acne, hirsuitism, masculinization, decreased HDL.
5 alpha reductase inhibitor. used in BPH, also promotes hair growth. To prevent male pattern hair loss, give a drug that will encourage female breast growth
A nonsteroidal competitive inhibitor of androgens at the testosterone receptor. Used in prostate cancer
Inhibits testosterone synthesis. Given in PCOS to prevent hirsuitism. Can cause gynecomastia and amenorrhea
A1 agonist used to treat BPH by inhibiting smooth muscle contraction. Doesn't affect vasculature.