Flashcards in Neuro Deck (11):
Bromocriptine (ergot), pramipexole, ropinerol (non ergot = preferred).
Drugs that increase dopamine
Amantadine may increase release
Drugs that prevent DA breakdown
Selegeline (MAOB inhibitor),
Entecapone/tolcapine (compt inhibitors, prevent dopa degradation in PNS)
Antimuscarinic, decreases cholinergic activity in brain. Little effect on bradykinesia but improves tremor and rigidity.
What specifically in PD is due to decreased DA?
Bradykinesia. So therefore, benztropine can't fix it.
Preferentially metabolizes dopamine oer NE and 5HT, so blocking it is good for PD.
NMDA receptor antagonist used for Alzheimers. Can prevent excitotoxiity. But can cause hallucinations
Donepezil, rivastigmine, galantamine
Ache inhibitors that increase cognition in AD
Tetrabenzine and reserpine, prevent VMAT and dopamine release.
5ht1d agonist. Ihbitis trigeminal nerve ativation.