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Flashcards in Neuro Deck (11):
1

Dopamine agonists

Bromocriptine (ergot), pramipexole, ropinerol (non ergot = preferred).

2

Drugs that increase dopamine

Amantadine may increase release
L-dopa/carbidopa

3

Drugs that prevent DA breakdown

Selegeline (MAOB inhibitor),
Entecapone/tolcapine (compt inhibitors, prevent dopa degradation in PNS)

4

Benzropine

Antimuscarinic, decreases cholinergic activity in brain. Little effect on bradykinesia but improves tremor and rigidity.

5

What specifically in PD is due to decreased DA?

Bradykinesia. So therefore, benztropine can't fix it.

6

MAOB

Preferentially metabolizes dopamine oer NE and 5HT, so blocking it is good for PD.

7

Memantine

NMDA receptor antagonist used for Alzheimers. Can prevent excitotoxiity. But can cause hallucinations

8

Donepezil, rivastigmine, galantamine

Ache inhibitors that increase cognition in AD

9

Huntington drugs

Tetrabenzine and reserpine, prevent VMAT and dopamine release.

Also haloperidol.

10

Sumatriptan

5ht1d agonist. Ihbitis trigeminal nerve ativation.

11

Toxicity of sumatriptan

Coronary artery vasosopasm. So don't use in CAD or prinzmetal.