Basal Ganglia Drugs Flashcards Preview

Neuro > Basal Ganglia Drugs > Flashcards

Flashcards in Basal Ganglia Drugs Deck (11):
1

D1 and D2 Rs

D1 on GABA neurons in striatum that project to direct pathway. Stimulated by DA.
D2 on GABA neurons projecting to indirect. Inhibited by DA

2

Parkinson's

Loss of DAergic neurons from SN, so lose activation of direct pathway and inhibition of indirect

3

2 Enzymes of DA Synth

Tyrosine hydroxylase converts tyr to Dopa, and Dopa decarboxylase converts Dopa to DA

4

2 Enzymes of DA Degradation

COMT and MAO. Can switch positions

5

Carbidopa (what it is and 2 effects)

Inhibitor of Aromatic L-AA decarboxylase, enzyme that converts L-Dopa to DA.
1. Increases drug in circulation bc stays as L-Dopa (form that can cross BBB
2. Reduces side effects bc less exogenous DA in periphery
Overall can lower the dose and have fewer side effects

6

4 Problems of PD Treatments

Dietary AAs compete w/ L-Dopa for transport from gut to circulation and circ into brain, so don't take w/ meals
GI problems and cardiac problems from periphery, so take w/ carbidopa
Degeneration of neurons continues and effectiveness of LDopa declines

7

3 Other PD D Drugs

Pergolide: D1 and 2 agonist
Bromocriptine: D2 agonist, restores indirect inhibition
Ropinirole: D2 agonist

8

Ach in Striatum

M1/M4 stimulate GABAs going to direct, M1 stimulates GABAs going to indirect

9

3 Ach PD Drugs

Benztropine: AChR antagonist
Trihexyphenidyl: M1 muscarinic R antagonist
Biperiden: M1 R antagonist

10

Huntington's Disease

Loss of GABAergic neurons in BG. Ones going to indirect pathway loss first so get hyperactivity

11

2 HD Drugs

Haloperidol - block DA Rs
Dizepam - enhance GABA Rs