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Flashcards in CNS Tumors Deck (19):
1

4.4 Kinds of Tumors

Meningiomas
Gliomas - astrocytomas, oligodendrogliomas, glioblastoma, and ependymoma
Primitive Neuroectodermal Tumors: medulloblastoma
Metastatic Tumors

2

Spread of CNS Tumors

Metastatic spread rare or absent: instead diffusely infiltrate adjacent brain

3

3 Ways Childhood Brain Tumors Differ from Adult

Infratentorial
Primitive tumors more common (neuroectodermal)
Metastases/meningiomas rare

4

Meningioma Radiologic View

Sharply demarcated, don't infiltrate, just compress

5

Meningioma Origin

Arachnoid cell subdural

6

Meningioma Histological Signs (2)

Whorls of tumor cells, which will eventually degrade/calcify to form psammmoma bodies

7

2.3 Kinds of Astrocytoma (and grades)

Pilocytic (good margin b/w it and brain): I
Diffuse Astrocytomas (more infiltrating):
Astrocytoma: II
Anaplastic astrocytoma: III
Glioblastoma: IV

8

Treatment for Diff Astrocytoma Grades

I: Just resect and observe, usuall fine
II: Observe, maybe radiation
III and IV: Radiation and chemo

9

Mural Nodule

Contrasting enhancing, sits inside cyst as sign of pilocytic astrocytoma

10

4 Features of Malignancy to Decide Grade

Anaplasia
Mitoses
Microvascular proliferation
Necrosis w/ pseudopalisading

11

Oligodendroglioma

Slow growing, w/ seizures. Grade II. "Fried egg appearance"

12

LOH 1p/19q

Mut of oligodendroglioma that correlates to improved chemo response

13

2 Histologic Features of Medulloblastomas

Sheets of primitive neuroectodermal cells (basophilic)
Homer-Wright rosettes (gather around central area of cytoplasm)

14

Most Common Brain Metastases

Lung and breast

15

Radiologic Features of Metastatic Tumor

Contrast enhacing ring around central area of necrosis

16

Medulloblastoma

Poorly differentiates neoplasms, more common younger, and in cerebellum

17

Grade I Pilocytic Astrocytoma

Tumors don't infiltrate normal brain tissue so surgery can be a cure

18

Glioblastoma Multioforme (3)

High grade, tumor crosses corpus callosum = butterfly
Causes vasogenic edea by increased permeability of bvs

19

Radiologic Sign of Meningioma

Homogenous enhancement on MRI w/ contrast