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Flashcards in CNS Infections Deck (19):
1

4 Mechs of Spread to CNS

Hematogenous
Direct extension (skin/sinuses/bone, like after trauma)
CSF
Axonal Transport

2

4 Kinds of Infections/Based on Inflammation (what diseases lead to and defining immune cells)

Acute/pyogenic (PMNs, pyogenic bacteria)
Subacute (lcytes, treated bacterial infections like syph)
Chronic (lcytes, viruses and fungus and shit)
Granulomatous (lcytes and giant cells and such. TB, leprosy, others)

3

3 Kinds of Meningitis

Bacterial (septic, PMNs, purulent)
Fungal (chronic inflammation, cryptococcus)
Virus (aseptic)

4

Neonatal Acute Bacterial Meningitis

Often vaginal delivery, E. coli and StrepBeta

5

Treatment of Brain Abscess (3)

Resection
Culture for Antibodies
Administer Antibodies (broad spectrum)

6

Acute Viral Meningitis

Usually self limiting and often viral cultures are negative, so called "aseptic"

7

3 Kinds of Chronic Bacterial Meningitis

TB
Neurosyph
Lyme disease

8

Pott's Disease

Epidural TB infection, extends to vertebral bone

9

Tabes Dorsalis

Degeneration of posterior columns from tertiary syphilis, loss of light touch and position sense

10

8 Kinds of Viral Meningoencephalitis

Arthropod borne, like equines and WNE
Polio
Rabies
HIV-1
Herpes simplex I and II
Varicella zoster
Cytomegalovirus
Progressive multifocal leukoencephalitis

11

HSV

Type I often encephalitis in children/young adults that necroses and hemorrhages frontal and temporal lobes so can be devastating
II often in adults, check mother and if positive do C section

12

Cowdry Type A Inclusions

Intranuclear eosinophilic inclusion seen w/ both types of HSV

13

Poliomyelitis

Spreads hemotagenously and infects LMNs, preferably AchRs. Get permanent loss of anterior horn cells

14

Difference b/w Negri bodies and Cowdry Type A inclusions

Negri seen in cytoplasm

15

Sign of HIV-1 Encephalitis (end stage AIDS)

Multinucleated monocytic cells

16

7 Opportunistic Infections

Toxoplasmosis
EBV: primary CNS lymphoma
PML from papomavirus
Cytomegalo
Varicella zoster
Cryptococcus
Syphilis

17

PML

Demyelinating disease from papovavirus? so gliotropic

18

5 Fungal Infections

Cryptococcus
Candida, aspergillus, and mucormycosis
Cystocercosis from Taenia solium (pig tapeworm) eggs

19

Sterilization Procedures for CJD

Much more intense: Steam autoclaving at 132degC for 1 hr, and formic acid