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Flashcards in Schizophrenia Deck (19):
1

Criteria for Schizo Diagnosis (3.5)

At least 2 of following, one of which should include 1-3: Delusions, hallucinations, disorganized speech, disorganized or catatonic behavior, negative symptoms
Marked by social/occupational impairment
Continuous signs for 6 months

2

Hallucinations vs. Delusions

False sensory perceptions in absence of external stimuli vs. Fixed false beliefs that persist despite clear evidence contrary

3

Kinds of Hallucinations in Schiz

Usually auditory, occasionally visual. Other senses point to tumor

4

Echolalia vs. Echopraxia

Imitation of speeech vs. movement

5

4.2 Catatonic Behaviors

Extreme Negativism: motiveless resistance to all instructions
Posturing: Rigidity or Waxy Flexibility (maintains those placed by examiner)
Stupor: immobile, mute
Excitement: excessive/aimless motor activity

6

5 Negative Symptoms

Avolition (lack of energy/routine activities)
Alogia (reduction in speech)
Anhedonia (inability to experience pleasure)
Asociality
Flat Affect

7

Significance of Negative Symptoms (3)

Hardest to diagnose
Often most debilitating part
Doesn't respond to antipsychs

8

Brief Psychotic Disorder

Basically schiz, symptoms last under a month

9

Schizoaffective Disorder

Like BPD, but psych syptoms whenever instead of just at extremes

10

2 Most Affected Cognitive Symptoms

Attention and working memory

11

Good Prognosis Indicators

Late onset and stable personal life

12

4 Schiz Genes

COMT - DA metabolism - + symptoms
GRM3 (metabotropic glu R): regulation of CNS, glu transmission
Dysbindin 1 - interneuronal connections
DISC1 - Affects hippocampal function

13

Neurodevelopmental Theory of Schizo

Not born with it, just a genetic propensity and then additional hits like viruses or pot can cause onset

14

Viral Etiology

Exposure to influenza in 2nd trimester

15

3 Glu Hypotheses of Schizo

1. NMDA Rs Hypofunction Hypothesis
2. Glu Excitotoxicity Neurodevelopmental Theory - excessive pruning
3. Glu Excititoxicity Neurodegenerative Theory - Excessive apoptosis

16

5 Phases of Disease Development

Premorbid
Prodromal
Florid
Recovery
Residual

17

Gross Features of Brain

Vents larger bc smaller brain w/ smaller, fewer neurons w/ fewer connections each

18

DA Hypothesis

Antipsychs all work blocking D2 R and DA metabolites correlate w/ level of positive symptoms

19

Family Environment Correlation

Only one that really correlated was "high expressed emotion" families had higher relapse rates