How are T cells activated?
The T cell receptor and MHC are both bound for activation
Subsequent binding from co-receptors (CD4 or CD8) enhance this activation and aid differentiation
What effect does the compromised skin barrier in eczema have?
Allows access and increased sensitisation to antigens
Promotes colonisation by microorganisms
Which MHC complex(es) is/are most problematic in terms of skin graft rejection?
MHC class 1
(presents self antigens, hence all will be foreign)
Which type of antigen does MHC class 1 present to cytotoxic T cells?
Which type of hypersensitivity is related to mast cell degranulation?
Describe the immunopathogenesis of psoriasis
Keratinocytes become under stress
Plasmacytoid dendritic cells secrete IFN alpha
Keratinocytes secrete IL-1 beta, IL-6 and TNF
Dermal dendritic cells activate and present to TH1 and TH17 cells
T cells enter the dermis and secrete IL-17A, IL-17F and IL-22
This induces keratinocyte prolifeation, antimicrobial protein release and neutrophil recruitment
Which type of cell comprises the keratin layer?
Which immune cells are most associated with atopic dermatitis?
Which immune cells are associated with psoriasis?
Which type of T cell is most prominent in the epidermis?
(CD4 and CD8 both found in dermis)
What is released by cells of the body when they become infected?
Type IV hypersensitivity is mediated by which immune cell?
Which dendritic cell is associated with diseased skin?
What is the main immune cell in the epidermis?
Which immune cell is most useful against worms and parasites?
Within the dermis, which dendritic cell is responsible for antigen presentation primarily?
Dermal dendritic cells
How do the roles of plasmacytoid dendritic cells and dermal dendritic cells differ?
Plasmacytoid - associated with disease skin and secrete INFa
Dermal - associated with antigen presentation in the dermis
Which type of T cell activates macrophages and how do they achieve this?
Release IL2 and IFN gamma
What is the name given to the characterstic tennis racket-shaped component of Langerhans cells?