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Flashcards in Pathology of Rashes Deck (51)
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1

Which type of dermatitis has a strong connection with coeliac disease?

Dermatitis herpetiformis

2

Pemphigus vulgaris is ____ mediated

Pemphigus vulgaris is IgG mediated

3

Pemphigus vulgaris is an autoimmune condition

True or false?

True

4

After taking a skin sample in a patient with rosacea, what is often seen under microscopy?

Demodex folliculorum mites

(in the pilosebaceous units)

5

In which situation may bellous pemphigoid mimic pemphigus vulgaris?

Older lesions of bullous pemphigoid heal and re-epithelialise making the lesions look as if they have involved the epidermis

6

Which type of pemphigus is the most common?

Pemphigus vulgaris

7

How does pemphigus vulgaris often begin?

Mouth blisters

8

How can pemphigus foliaceus be differentiated from pemphigus vulgaris?

Mouth blistering does not occur

9

Which type of pemphigus is described by:

"Thick painful lesions develop in the groin and axilla region"?

Pemphigus vegetans

10

Which type of pemphigus is described by:

"Blistering usually begins on the face and scalp which progresses to the chest and back. Blisters are not sore, but itchy. The skin is host to numerous moist scales and there are no mouth ulcers"

Pemphigus foliaceus

11

What is the least harmful variant of pemphigus?

IgA pemphigus

12

IgA pemphigus is most visually similar to which other form of pemphigus?

Pemphigus foliaceus

13

Which type of pemphigus is very rare and associated with people suffering from cancer?

Paraneoplastic pemphigus

14

What are potential signs and symptoms for paraneoplastic pemphigus?

  1. Mouth and lip sores
  2. Lesions on the eye and eyelid lining
  3. Skin blistering
  4. Serious lung issues

It is a very challenging condition to diagnose

15

Which features are associated with Rosacea?

  1. Recurrent facial flushing
  2. Telangiectasia
  3. Pustules
  4. Thickening of the skin
  5. Rhinophyma

16

Rosacea is more common in which gender?

Females

17

Where are blisters usually present within the skin in a patient with bullous pemphigoid?

Basement membrane of the epidermis

18

Which factors can aggravate rosacea?

  1. Hot/spicy food
  2. Exercise
  3. Emotion
  4. Alcohol
  5. Sunlight

19

Which term refers to the persistance of nuclei within the keratin layer?

Parakeratosis

20

What is the process behind the development of pemphigus vulgaris?

  1. IgG antibodies form to desmoglein 3
  2. Desmosomal attachments are destroyed as immune complexes form and complement/proteases are released
  3. Blisters form
  4. Acantholysis occurs - the loss of intercellular connections

21

Spongiotic oedema is characteristic of which condition?

Eczema

22

In psoriasis, new lesions form at sites of trauma, what is the term given to describe this?

Koebner phenomenon

23

What do immunobullous diseases involve?

Formation of vesicles and bullae

24

What is the epidermal basement membrane composed of?

Laminin and collagen type IV

25

Why does acne affect adolescents worse than other age groups?

  1. Androgens increase the size of sebaceous glands
  2. Sebum production increases

26

Which factor is common to all type of pemphigus

Acantholysis

27

Which type of collagen is bundled in the reticular dermis?

Type 1

28

What is the hallmark of dermatitis herpetiformis?

Papillary dermal microabscesses

29

In which way do melanocytes look distinctive?

Cells with a pale halo

30

Which type of people does pemphigus characteristally affect?

Ashkenazi Jewish origin