Cutaneous Drug Eruptions Flashcards Preview

Dermatology > Cutaneous Drug Eruptions > Flashcards

Flashcards in Cutaneous Drug Eruptions Deck (22)
Loading flashcards...
1

Drug induced bullous pemphigoid is associated with which drug?

ACE inhibitors

Furosemide

Penicillin

2

What is the most common morphology of drug eruption in the skin?

Exanthematous/Morbilliform/Macropapular - 75-95%

(urticarial is second most common)

3

Which features indicate that an exanthemous drug eruption is severe?

Involvement of mucous membranes and face

Facial oedema and erythema

Widespread confluent erythema

Fever

Blisters

Purpura

Necrosis

4

What comprises an urticarial rash?

Erythema and wheals

5

Which type of hypersensitivity is associated with pemphigus and pemphigoid?

Type II

6

Which hypersensitivity type is associated with eczema?

It is not immunologically mediated

7

Linear IgA disease can be brought on by which drug?

Vancomycin

8

Where is the deposition of IgA in linear IgA disease?

Along the basement membrane

9

How are blisters arranged in linear IgA disease?

A string of peals

10

What is linear IgA disease?

IgA is deposited at the basement membrane

Paients present with pemphigoid or dermatitis herpitiformis like presentations, but IgA is present instead of IgG at the basement membrane

It is associated with Vancomycin

11

Which types of drugs are associated with pustular/bullous drug eruptions (acne)?

Glucocorticoids

Androgens

Lithium

Isoniazid

Phenytoin

12

Which type of drug reaction is associated with immediate prickling with delayed erythema and pigmentation?

Photosensitivity

13

Which drgs are commonly associated with photosensitivity

Amiodarone

Chlorpromazine

Thiazides

NSAIDs

Psoralens

Antibiotics (fluroquinolones, tetracyclines)

14

Exanthematous drug eruptions are caused due to what?

Type IV

(usually mild and self limiting widespread rash which avoids the mucous membranes)

15

Which type of symptoms are associated with Stevens-Johnsons syndrome and Toxic Epidermal Necolysis

Cutaneous and systemic

16

Which drugs have fixed drug eruptions?

Tetracycline

Doxycyline

Paracetamol

NSAIDs

Carbamazepine

17

How can fixed drug eruptions be described?

Well demarkated plaques (round/ovoid) which resolve with persistant pigmentation after drug withdrawal

18

Where do fixed drug eruptions typically occur?

Hands

Genitalia

Lips

Oral mucosa (occasional)

19

Fixed drug eruptions will occur on the ________ ________ if the drug is reintroduced

Fixed drug eruptions will occur on the same site if the drug is reintroduced

20

Which sex is more susceptible to drug eruptions?

Females

21

What is the normal time frame for a type IV hypersensitivity reaction?

4-21 days

22

Which type of hypersensivity reaction is psoriasis associated with?

It is not immunologically mediated