Flashcards in Biochemistry Deck (255)
Apo B 100 vs. 48
ApoB-100 is synthesized by the liver and binds LDL receptor for LDL uptake. ApoB-48 is truncated form synthesized in the intestines and incorporated into chylomicrons (via cytidine to uridine deamination reaction on transcribed mRNA -> premature stop).
Down syndrome characteristics
ID, epicanthal, flat face, cleft palate, nuchal fold, palmar simian crease, endocardial cushion, duodenal/jejunal atresia, hypotonia, gap between 1-2nd toes
Absorption of B12?
(1) Requires salivary R protein to bind B12 and protect it from acid. It also binds B12 released from acidified food in the stomach (2) Pancreatic enzymes cleave R protein from B12, allowing it to bind to intrinsic factor (made by parietal cells) -> absorption at terminal ileum.
Familial Dyslipidemia Type I
I - hyperchylomicronemia. AR. Lipoprotein lipase deficiency or altered C-II. Pancreatitis, hepatosplenomeg, xanthomas.;
Familial Dyslipidemia Type IIa
IIa - familial hypercholesterolemia. AD. LDLR. Heteros have chol 300, homozys with 700+. Acc. atherosclerosis, tendon xanthomas, corneal arcus;
Familial Dyslipidemia Type IV
IV - hypertriglyceridemia. AD. Overproduction of VLDL. Pancreatitis.
Degrades TG's in chylo and VLDL's
Hepatic TG lipase
Degrades TG's into IDL
Puts TG into adipocytes
Esterifies cholesterol into nascent HDL to make mature?
Transfers cholesterol esters from mature HDL to other lipoproteins
Apo B-48 vs. B100
Chylomicron secretion vs extrahepatic uptake
A-I - activates LCAT
Lipoprotein lipase cofactor. Familial chylomicronemia syndrome (Acute pancreatitis)