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Flashcards in Biochemistry Deck (255)
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241

Apo B 100 vs. 48

ApoB-100 is synthesized by the liver and binds LDL receptor for LDL uptake. ApoB-48 is truncated form synthesized in the intestines and incorporated into chylomicrons (via cytidine to uridine deamination reaction on transcribed mRNA -> premature stop).

242

Down syndrome characteristics

ID, epicanthal, flat face, cleft palate, nuchal fold, palmar simian crease, endocardial cushion, duodenal/jejunal atresia, hypotonia, gap between 1-2nd toes

243

Absorption of B12?

(1) Requires salivary R protein to bind B12 and protect it from acid. It also binds B12 released from acidified food in the stomach (2) Pancreatic enzymes cleave R protein from B12, allowing it to bind to intrinsic factor (made by parietal cells) -> absorption at terminal ileum.

244

Familial Dyslipidemia Type I

I - hyperchylomicronemia. AR. Lipoprotein lipase deficiency or altered C-II. Pancreatitis, hepatosplenomeg, xanthomas.;

245

Familial Dyslipidemia Type IIa

IIa - familial hypercholesterolemia. AD. LDLR. Heteros have chol 300, homozys with 700+. Acc. atherosclerosis, tendon xanthomas, corneal arcus;

246

Familial Dyslipidemia Type IV

IV - hypertriglyceridemia. AD. Overproduction of VLDL. Pancreatitis.

247

Lipoprotein lipase

Degrades TG's in chylo and VLDL's

248

Hepatic TG lipase

Degrades TG's into IDL

249

Hormone-sensitive lipase

Puts TG into adipocytes

250

LCAT

Esterifies cholesterol into nascent HDL to make mature?

251

CETP

Transfers cholesterol esters from mature HDL to other lipoproteins

252

Apo B-48 vs. B100

Chylomicron secretion vs extrahepatic uptake

253

Apo A-1

A-I - activates LCAT

254

Apo C-II

Lipoprotein lipase cofactor. Familial chylomicronemia syndrome (Acute pancreatitis)

255

ApoE 3 & 4

ApoE-3 &4 - VLDL and chylomicron remnant uptake by liver (ApoE4 associated w/ late-onset AD)