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Flashcards in Bioenergetics Deck (20):
1

This pathway is a series of chemical reactions that synthesize biomolecules from smaller units. (consume ATP)

anabolic

2

This pathway is a series of chemical reactions that break down biomolecules into smaller units. (releases ATP)

catabolic

3

What is the first law of thermodynamics?

energy can neither be created or destroyed

4

Is the free energy of an endergonic reaction positive or negative? favorable or unfavorable?

postive; unfavorable

5

Is the free energy of an exergonic reaction positive or negative? favorable or unfavorable?

negative; favorable

6

The change in free energy of a chemical reaction is related to ___ ____

equilibrium constant

7

When the equilibrium constant is less than 1, the reaction is ____ and deltaG' is ____. When the equilibrium constant is greater than 1, the reaction is ____ and deltaG' is ___.

energonic; postive

exergonic; negative

8

In most cells, the process of oxidation of glucose occurs in aerobic or anaerobic conditions?

aerobic

9

Aerobic glucose oxidation provides how many molecules of ATP?

38

10

Carbohydrates and proteins have a coloric value of __-___ KJ/g, while lipids have __ times higher value

12-16; 3

11

Carbon atoms in carbohydrates are ___ ___ than those in lipids

more oxidized

12

RBCs and the adult brain in fed state use only ___ as a source of energy, whereas the liver of a diabetic or fasted individual metabolizes primarly ___ to meet the energy demand

carbohydrates; lipid

13

The essential link in bioenergetics is ATP between energy ___ and ___ pathways

producing; utilizing

14

What is the result of Mg2+ binding to ATP?

Mg2+ draws electron density from the oxygens and makes the phosphate more electronegative and easier to be attacked by H2O

15

What do Mutations D32V and A63P of mycobacterium do?

ATP synthase c-subunit confer ristance to tuberculosis drugs

16

___ is active against a number of drug-resistant strains of TB. What is its mechanism?

Bedaquiline; blocks ATP synthesis

17

This is a primary microbial agent in the pathogensis of dental cavities through biofilm formation and acid production.

Strep mutans

18

Inhibition of ATP synthase of S. mutans inhibits biofilm formation and acid production. What can be used to accomplish this?

dietary polyphenols 

19

The inhibition of non-mitochondrial endothelial cell surface ATP synthase blocks tumor _____

angiogenesis

20

many anti-angiogenisis agents such as resveratrol and piceatannol block tumor growth by binding to the subunit ___ of ATP synthase

F1