Flashcards in Regulation of Enzymes Deck (11):
In regards to synthesis and degradation, since Vmax = K3[Etotal], one way to increase or decrease activity is to increase or decrease ____
By keeping enzymes, cofactors and substrates of two conflicting pathways physically separate, futile cycling of substrates is avoided. Give an example of this.
FA synthesis occurs in the cytosol
FA oxidation occurs in the mitochondria
Many hormones produce "second messengers" which are allosteric effectors of various enzymes and tissues. One popular second messenger that binds various enzymes, altering their activity is ___
Some hormones increase the cytosolic ____, which interacts with a protein called calmodulin.
What happens to the Ca2+ - calmodulin complex?
affects the activity of a number of proteins
Phosphorylation is a type of ___ regulation
Phosphorylation is accomplished by a protein ___ which may be very specific for the enzyme or protein to be phosphorylated or may be broad in its specificity
Dephosphorylation is accomplished by a protein ____
In regards to proteolytic activation, some enzymes are synthesized in inactive form (zymogen or proenzyme). How are they activated?
What are some examples of digestive proteases (proteolytic enzymes)? Coagulation zymogens?
digestive proteases: trypsinogen, chymotripsinogen
coagulation zymogens: fibrinogen, prothrombin, etc