BL - Connective And Adipose Tissues Flashcards Preview

CJ: UoL Medicine Semester One (ESA1) > BL - Connective And Adipose Tissues > Flashcards

Flashcards in BL - Connective And Adipose Tissues Deck (37):
1

What are the four types of tissue?

Epithelial, muscle, nerve, connective

2

Name some types of specialised connective tissues. (6)

Adipose, lymphatic, blood, haemopoietic, cartilage, bone

3

List some functions of connective tissue. (6)

CONNECTS cells, tissues and organs; TRANSPORTS nutrients/wastes; PROTECTS (cushions/insulates); STORES fat; DEFENDS against infection; HEALS

4

What does CT proper consist of and contain?

Consists of loose CT + dense CT

Contains cells, fibres and ground substance

5

Name the three fibres found in connective tissue.

Collagen (flexible and strong)
Reticular (provides framework)
Elastin (allows tissues to recoil)

6

Which disease occurs due to lack of vitamin C affecting collagen production?

Scurvy - poor wound healing and impaired bone formation.

7

How is collagen produced?

FIBROBLASTS secrete PRE-COLLAGEN that is converted to collagen molecules OUTSIDE the cell. The collagen molecules are then AGGREGATED to form the final collagen fibrils.

8

How is type one collagen (98% of all collagen) structured?

It is formed of a triple helix of alpha chains.

9

How is type three collagen (reticulin) structured?

FIBRILS form FIBRES around muscle and nerve cells and within lymphatic tissues and organs.

10

What disease results from abnormal type one collagen?

Osteogenesis imperfecta

11

What is the primary component of elastic fibres (which occur in most connective tissues)?

Elastin, but it enfolds and is surrounded by fibrillin.

12

Where does elastin play an important role?

Dermis, artery walls, lungs, other sites bearing elastic cartilage

13

Which syndrome occurs when expression of the fibrillin gene is abnormal?

Marfan's Syndrome

14

What is ground substance?

A viscous clear substance with a slippery feel made from proteoglycans

15

What are proteoglycans?

Large macromolecule consisting of a core protein to which glycosaminoglycans are covalent bonded.

16

What are glycosaminoglycans?

Long chain polysaccharides which attract water to form a gel, e.g. hyaluronic acid

17

What is the extracellular matrix?

Complex extracellular structural network that consists of ground substance and fibres

18

List the characteristics of loose connective tissue

Many cells, not many collagen fibres, lots of ground substance, viscous, important for diffusion

19

Where is loose connective tissue mostly found?

Beneath epithelia, around epithelium of glands, around blood vessels (so can swell if pathogens enter).

20

List the characteristics of dense connective tissue

Few cells (mostly fibroblasts), many collagen fibres, not much ground substance

21

Which type of dense connective tissue has collagen fibres in densely packed parallel bundles with fibroblasts in them?

Regular - can withstand stress in one direction

22

Which type of dense CT has collagen fibres in random bundles with fibroblasts?

Irregular - can withstand stress in multiple directions

23

What connects muscles to bones and has parallel collagen bundles?

Tendons

24

What connects bones to bones and has densely packed collagen bundles?

Ligaments

25

What is an aponeurosis?

A flat sheet of regular CT with criss-crossing bundles of fibres

26

Which sort of tissue is the dermis made out of?

Dense irregular, as bundles of collagen resist tearing of skin

27

What do fibroblasts synthesise and secrete?

Ground substance and the fibres within it

28

Which actin-containing cell causes the wound to contract?

Myofibroblasts

29

Which cells move into inflamed loose CT?

Macrophages

30

Where are mast cells found in CT?

Found in connective tissue near blood vessels BUT not by nerves as swelling would damage them. Can cause anaphylaxis.

31

How are histamine and heparin released from the granules?

Cells are coated with IgE which binds allergens. When an allergen cross links, contents of the granules are rapidly released from the cell.

32

Name the two types of fat cells

White and brown

33

Which type of fat cell is almost entirely filled by one fat droplet, squashing the nucleus and cytoplasm?

White fat cells

34

Which type of fat cell contains multiple droplets and a central nucleus?

Brown fat

35

Why is brown fat brown?

Rich vascular supply and mitochondria so can generate heat.

36

What is ghrelin?

Appetite stimulator released from stomach

37

What is leptin?

Appetite SUPPRESSOR released by fat cells when eating.

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