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Flashcards in Block 3 Biochem Deck (126)
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1

what is the committed reaction in steroid hormone sythesis?

cholesterol to pregnenolone

2

3 hydroxylations of progesterone makes

cortisol

3

2 hydroxylations and an oxidation of progesterone makes

aldosterone

4

3 beta hydroxysteroid dehyd. deficiency results in

pregnenolone buildup, marked salt excretion. also female genitalia

5

17 alpha hydroxylase deficiency results in

no sex hormones or cortisol. more aldosterone made

6

21 alpha hydroxylase deficiency-

no gluco or mineralocorticoids made

7

Angiotensin activates what protein kinase to stimulate aldosterone?

PKC

8

pepsinogen is secreted by _____

chief cells

9

pepsin is a ______ protease

aspartate

10

HCl is secreted by _______

parietal cells

11

signals the release of bicarb from the pancreas-

secretin

12

what converts trypsinogen to trypsin?

enteropeptidase

13

what activates most pancreatic zymogens?

trypsin

14

serine proteases are what kind of peptidases?

endopeptidases

15

trypsin cuts at what AA's

C terminus arginines and lysines

16

elastase cuts what kinds of AA's

small ones (ala, gly, ser)

17

are metallopeptidases endo or exo peptidases?

exo

18

Defect in COAL transport can lead to

cystinuria

19

hartnup disorder-

inability to reabsorb bulky AA's

20

what coenzyme do aminotransferases use?

PLP (B6) derivative

21

which 2 aa's do not undergo aminotransferase rxns

lysine and threonine

22

where is DAO located?

in peroxisomes

23

Cahill cycle-

alanine from muscle is transported to liver to be converted to pyruvate

24

blood sugar conversion factor. 1 mM = __ mg/dL

18

25

list the 4 metabolic enzymes that are active while phosphorylated

hormone sensitive lipase, glycogen phosphorylase kinase, and glycogen phosphorylase, fructose bisphosphate phosphatase 2

26

binge drinking can drive OAA towards malate production, leading to

alcoholic ketoacidosis, as there is now excess acetyl CoA

27

after 3 weeks of fasting, muscle quits using ketone bodies for energy, only using FFA. This makes it easier for....

brain to use ketone bodies

28

during prolonged fasting, what provides 50% of glucose to muscle?

kidneys

29

which secretion of adipose tissue improves insulin sensitivity?

adiponectin

30

as we get fatter, what happens to adiponectin levels?

they decrease