Flashcards in Block 3 Phys Deck (306)
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1
ADH V1 receptor is
alpha q-- smooth muscle
2
ADH V2 receptor is
alpha s -- kidney
3
90% of filtered water is reabsorbed in the _____ tubule by _______
proximal
AQP1
4
only AQP responsive to ADH
AQP2
5
How does water leave the basolateral membrane of the collecting duct?
AQP 3&4
6
Which is more sensitive to dehydration (leading to AVP release) baroreceptors or osmoreceptors?
osmoreceptors
7
which neurons sends hormones to the posterior pituitary?
magnocellular
8
somatostatin stimulates the release of what hormone from anterior pituitary?
GH
9
AVP and oxytocin are made in what hypothalamnic nuclei?
SON and PVN
10
Ca-calmodulin activates ________
MLCK
11
what is SIADH
syndrome of inappropriate ADH secretion
12
bad taste in mouth is a symptom of what syndrome?
SIADH
13
decreased ADH release is often a complication of
diabetes insipidus
14
anterior pituitary is derived from _____derm
ecto
15
the 3 glycoprotein hormones of the anterior pituitary
TSH FSH and LH
16
all 3 glycoprotein hormones of the anterior pituitary have similar __ subunits and dissimilar ___ subunits
-alpha
-beta
17
pro-opiomelanocortin is cleaved into what hormones
ACTH, beta endorphin, alpha/beta/gamma melanocyte stimulating hormones
18
Growth hormone release is stimulated by _____glycemia and suppressed by ____glycemia
-hypo
-hyper
19
major players in GH release
GHRH and ghrelin
20
minor regulators of GH release
acetylcholine, alpha-adrenergic agonists, dopamine, serotonin
21
GH release is inhibited by
somatostatin and IGF-1
22
a long term increase in GH has what effect on adipose tissue?
anti insulin effect
23
laron's syndrome
GH resistance
24
low GH in adults is associated with
CV risk and muscle loss
25
Hypothalamus controls prolactin by maintaining inhibitory tone via
dopamine
26
Prolactin requires what other 2 things for milk production
insulin and cortisol
27
Long term increases in prolactin lead to
infertility and gonadal dysfunction
28
Increase in prolactin leads to decreases in what hormones?
LSH, FSH, gonadal steroidogenesis, estrogen, testosterone, progesterone
29
What inhibits release of TSH from anterior pituitary?
dopamine, somatostatin, and high levels of glucocorticoids
30
