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Flashcards in BLOCKERS Deck (20):
1

Nonselective alpha-blocking drug, long acting and irreversible, and used to treat pheochromocytoma. Blocks 5-HT, so occasionaly used for carcinoid tumor. Blocks H1 and used in mastocytosis

Phenoxybenzamine

2

Nonselective alpha-blocking drug, short acting and reversible, used for rebound HTN from rapid clonidine withdrawal, and Raynaud's phenomena

Phentolamine

3

Selective Alpha 1 blocker used for hypertension, BPH, may cause first dose orthostatic hypotension

Prazosin, terazosin, doxazosin

4

Selective Alpha 2 blocker used for impotence (controversial effectiveness)

Yohimbine

5

Selective B1 Receptor blockers that may be useful in treating cardiac conditions in patients with asthma

Acebutolol, atenolol, esmolol, metoprolol

6

Combined alpha and beta blocking agents that may have application in treatment of CHF

Labetalol and carvedilol

7

Beta blockers partial agonist activity (intrinsic sympathomimetic activity) cause some bronchodilation and may have an advantage in treating patients with asthma

Pindolol and acebutolol

8

This beta blocker lacks local anesthetic activity (decreases protective reflexes and increases the risk of corneal ulceration) and used in treating glaucoma

Timolol

9

This parenteral beta blocker is a short acting

Esmolol

10

This beta blocker is the longest acting

Nadolol

11

These beta blockers are less lipid soluble

Acebutolol and atenolol

12

This beta blocker is highly lipid soluble and may account for side effects such as nightmares

Propranolol

13

Clinical uses of these agents include treatment of HTN, angina, arrhythmias, and chronic CHF

Beta blockers

14

Toxicity of these agents include bradycardia, AV blockade, exacerbation of acute CHF, signs of hypoglycemia may be masked (tachycardia, tremor, and anxiety)

Beta blockers

15

Cholinomimetics that increase outflow, open trabecular meshwork, and cause ciliary muscle contraction

Pilocarpine, carbachol, physostigmine

16

Nonselective alpha agonists that decrease aqueous production and increase aqueous outflow

Epinephrine, dipivefrin

17

Selective alpha agonists that decreases aqueous secretion

Apraclonidine, brimonidine

18

These Beta blockers decrease aqueous secretion

Timolol (nonselective), betaxolol (selective)

19

This diuretic decreases aqueous secretion due to lack of HCO3- ion. Causes drowsiness and paresthesias, alkalinization of the urine may precipitate calcium salts, hypokalemia, acidosis

Acetazolamide

20

This agent cause increased aqueous outflow

Prostaglandin PGF2a (latanoprost, travoprost, unoprostone)