COAG.HYPERLIPID

Question 1

Vitamin K dependent anticoagulant

Answer 1

Warfarin (PT)

Question 2

Warfarin is contraindicated in

Answer 2

Pregnancy

Question 3

Anticoagulant of choice in pregnancy

Answer 3

Heparin

Question 4

Heparin (PTT) increases activity of

Answer 4

Antithrombin 3

Question 5

Route of administration of warfarin

Answer 5

Oral

Question 6

Routes of administration of heparin

Answer 6

IV and subQ

Question 7

SE of both warfarin and heparin

Answer 7

Bleeding

Question 8

SE of heparin

Answer 8

Heparin induced thrombocytopenia (HIT)

Question 9

Alternative anticoagulant used if HIT develops

Answer 9

Lepirudin

Question 10

Antidote to reverse actions of warfarin

Answer 10

Vitamin K or fresh frozen plasma

Question 11

Antidote to reverse actions of heparin

Answer 11

Protamine sulfate

Question 12

MOA of aspirin

Answer 12

Irreversibly blocks COX1 and COX2

Question 13

Agent used to treat MI and to reduce incidence of subsequent MI

Answer 13

Aspirin

Question 14

SE of Aspirin

Answer 14

GI bleeding

Question 15

Antiplatelet drug reserved for patients allergic to aspirin

Answer 15

Ticlopidine

Question 16

SE for ticlopidine

Answer 16

Neutropenia and agranulocytosis

Question 17

Effective in preventing TIA’s

Answer 17

Clopidogrel and ticlopidine

Question 18

Prevents thrombosis in patients with artificial heart valve

Answer 18

Dipyridamole

Question 19

Block glycoprotein IIb/IIIa involved in platelet cross-linking

Answer 19

Abciximab, tirofiban and eptifibatide

Question 20

MOA of thrombolytics

Answer 20

Lyse thrombi by catalyzing the formation of plasmin which binds fibrin

Question 21

Thrombolytics are used for

Answer 21

Pulmonary embolism and DVT

Question 22

Thrombolytic that can cause allergic reaction

Answer 22

Streptokinase

Question 23

Thrombolytic used for acute MI and ischemic (non hemorrhagic) CVA

Answer 23

Tissue plasmin activator

Question 24

SE of tPA

Answer 24

Cerebral hemorrhage

Question 25

Antidote for thrombolytics

Answer 25

Aminocaproic acid

Question 26

Agent to treat hypochromic microcytic anemias

Answer 26

Ferrous sulfate

Question 27

Chelating agent used in acute iron toxicity

Answer 27

Deferoxamine

Question 28

Agent for pernicious anemia

Answer 28

Cyanocobalamin (Vit B12)

Question 29

Agent used for neurological deficits in megaloblastic anemia

Answer 29

Vitamin B12

Question 30

Agent used for megaloblastic anemia (but does NOT reverse neurologic symptoms) and decrease neural tube defects during pregnancy

Answer 30

Folic acid

Question 31

Agent used for anemias associated with renal failure

Answer 31

Erythropoietin

Question 32

Agent used neutropenia especially after chemotherapy

Answer 32

G-CSF (filgrastim) and GM-CSF (sargramostim)

Question 33

Treatment of patients with prior episodes of thrombocytopenia after a cycle of cancer chemotherapy

Answer 33

Interleukin 11 (oprelvekin)

Question 34

Decrease intestinal absorption of cholesterol

Answer 34

Bile acid-binding resins

Question 35

Cholestyramine and colestipol are

Answer 35

Bile acid-binding resins

Question 36

Major nutritional side effect of bile acid-binding resins

Answer 36

Impair absorption of fat soluble vitamin absorption (A,D,E,K)

Question 37

MOA of lovastatin (STATIN)

Answer 37

inhibits HMG COA reductase

Question 38

HMG CoA reductase inhibitors are contraindicated in

Answer 38

Pregnancy

Question 39

How drug or foods (grapefruit juice) increase statin effect

Answer 39

Inhibit Cytochrome P450 3A4

Question 40

SE of HMG COA reductase inhibitors

Answer 40

Rhabdomyolysis and Hepatotoxicity

Question 41

Monitoring parameter to obtain before initiation of STATINS

Answer 41

LFT's

Question 42

Decreases liver triglycerol synthesis

Answer 42

Niacin

Question 43

SE of niacin

Answer 43

Cutaneous flush

Question 44

Cutaneous flush due to niacin can be reduced by pretreatment with

Answer 44

Aspirin

Question 45

Fibrates (gemfibrozil) increase activity of

Answer 45

Lipoprotein lipase

Question 46

Most common SE of fibrates

Answer 46

Nausea

Question 47

Fibrates are contraindicated in

Answer 47

Pregnancy

Question 48

Concurrent use of fibrates and statins increases risk of

Answer 48

Rhabdomyolysis

Question 49

Class of drugs that works by inhibiting absorption of intestinal cholesterol and can be given concurrently with the Statins

Answer 49

Ezetimibe (Zetia)