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Flashcards in COAG.HYPERLIPID Deck (49):
1

Vitamin K dependent anticoagulant

Warfarin (PT)

2

Warfarin is contraindicated in

Pregnancy

3

Anticoagulant of choice in pregnancy

Heparin

4

Heparin (PTT) increases activity of

Antithrombin 3

5

Route of administration of warfarin

Oral

6

Routes of administration of heparin

IV and subQ

7

SE of both warfarin and heparin

Bleeding

8

SE of heparin

Heparin induced thrombocytopenia (HIT)

9

Alternative anticoagulant used if HIT develops

Lepirudin

10

Antidote to reverse actions of warfarin

Vitamin K or fresh frozen plasma

11

Antidote to reverse actions of heparin

Protamine sulfate

12

MOA of aspirin

Irreversibly blocks COX1 and COX2

13

Agent used to treat MI and to reduce incidence of subsequent MI

Aspirin

14

SE of Aspirin

GI bleeding

15

Antiplatelet drug reserved for patients allergic to aspirin

Ticlopidine

16

SE for ticlopidine

Neutropenia and agranulocytosis

17

Effective in preventing TIA's

Clopidogrel and ticlopidine

18

Prevents thrombosis in patients with artificial heart valve

Dipyridamole

19

Block glycoprotein IIb/IIIa involved in platelet cross-linking

Abciximab, tirofiban and eptifibatide

20

MOA of thrombolytics

Lyse thrombi by catalyzing the formation of plasmin which binds fibrin

21

Thrombolytics are used for

Pulmonary embolism and DVT

22

Thrombolytic that can cause allergic reaction

Streptokinase

23

Thrombolytic used for acute MI and ischemic (non hemorrhagic) CVA

Tissue plasmin activator

24

SE of tPA

Cerebral hemorrhage

25

Antidote for thrombolytics

Aminocaproic acid

26

Agent to treat hypochromic microcytic anemias

Ferrous sulfate

27

Chelating agent used in acute iron toxicity

Deferoxamine

28

Agent for pernicious anemia

Cyanocobalamin (Vit B12)

29

Agent used for neurological deficits in megaloblastic anemia

Vitamin B12

30

Agent used for megaloblastic anemia (but does NOT reverse neurologic symptoms) and decrease neural tube defects during pregnancy

Folic acid

31

Agent used for anemias associated with renal failure

Erythropoietin

32

Agent used neutropenia especially after chemotherapy

G-CSF (filgrastim) and GM-CSF (sargramostim)

33

Treatment of patients with prior episodes of thrombocytopenia after a cycle of cancer chemotherapy

Interleukin 11 (oprelvekin)

34

Decrease intestinal absorption of cholesterol

Bile acid-binding resins

35

Cholestyramine and colestipol are

Bile acid-binding resins

36

Major nutritional side effect of bile acid-binding resins

Impair absorption of fat soluble vitamin absorption (A,D,E,K)

37

MOA of lovastatin (STATIN)

inhibits HMG COA reductase

38

HMG CoA reductase inhibitors are contraindicated in

Pregnancy

39

How drug or foods (grapefruit juice) increase statin effect

Inhibit Cytochrome P450 3A4

40

SE of HMG COA reductase inhibitors

Rhabdomyolysis and Hepatotoxicity

41

Monitoring parameter to obtain before initiation of STATINS

LFT's

42

Decreases liver triglycerol synthesis

Niacin

43

SE of niacin

Cutaneous flush

44

Cutaneous flush due to niacin can be reduced by pretreatment with

Aspirin

45

Fibrates (gemfibrozil) increase activity of

Lipoprotein lipase

46

Most common SE of fibrates

Nausea

47

Fibrates are contraindicated in

Pregnancy

48

Concurrent use of fibrates and statins increases risk of

Rhabdomyolysis

49

Class of drugs that works by inhibiting absorption of intestinal cholesterol and can be given concurrently with the Statins

Ezetimibe (Zetia)