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Flashcards in CARDIAC Deck (47):
1

MOA of class I A (eg. Procainamide), class IB (eg. Lidocaine), and class IC (eg. Flecainide) antiarrhythmics

Sodium channel blockers

2

SE of procainamide

Lupus-like syndrome

3

Limiting side effect of Quinidine

Prolongs QT interval

4

Other side effects of Quinidine

Thrombocytopenic purpura, and CINCHONISM

5

Major drug interaction with Quinidine

Increases concentration of Digoxin

6

DOC for management of acute Ventricular arrhythmias

Lidocaine

7

DOC for digoxin induced arrhythmias

Phenytoin

8

SE of phenytoin

Gingival hyperplasia

9

Class of anti-arrhythmics that has a pro-arrhythmic effect (CAST trial), therefore are used as last line agents

Class IC (flecainide, propafenone, moricizine)

10

Class II antiarrhythmics are

B-blockers

11

Antiarrhythmic that exhibits Class II and III properties

Sotalol

12

Side effect of sotalol

prolongs QT and PR interval

13

Used intravenously for acute arrhythmias during surgery

Esmolol

14

Anti-arrhythmics that decrease mortality

B-blockers

15

MOA of class III antiarrhythmics

Potassium channel blockers

16

Class III antiarrhythmic that exhibits properties of all 4 classes

Amiodarone

17

Specific pharmacokinetic characteristic of amiodarone

Prolonged half-life, up to six weeks

18

Antiarrhythmic effective in most types of arrhythmia

Amiodarone

19

SE of Amiodarone

Thyroid dysfunction, photosensitivity, skin (blue smurf syndrome), corneal deposits, liver damage and pulmonary fibrosis

20

MOA of class IV antiarrhythmics

Calcium channel blockers

21

Life threatening cardiac event that prolong QT leads to

Torsades de pointes

22

Agent to treat torsades de pointes

Magnesium sulfate

23

Drug used supraventricular arrhythmias

Digoxin

24

DOC for paroxysmal supraventricular tachycardia (PSVT)

Adenosine

25

Adenosine's MOA

Activates acetylcholine sensitive K+ channels in SA and AV node

26

Anti-arrhythmic with <10 second duration of action

Adenosine

27

MOA of sildenafil (Viagra)

Inhibits phosphodiesterase-5, enhancing effects of nitric oxide-activated increases in cGMP

28

Drugs used in the management of angina

Aspirin, Nitrates, CCB, and Beta blockers

29

Aspirin reduces mortality in unstable angina by

Platelet aggregation inhibition

30

MOA of nitrates

Relax vascular smooth muscle, at low doses dilate veins and at high doses dilate arterioles

31

Nitrate used for acute anginal attacks

Nitroglycerin sublingual tablets

32

Nitrate used to prevent further attacks

Oral and transdermal forms of nitroglycerin

33

Nitrate free intervals are needed due to

Tolerance

34

SE of nitrates

Postural hypotension, reflex tachycardia, hot flashes, and throbbing headache due to meningeal artery dilation

35

CCB are DOC for

Prinzmetal's angina

36

Beta blockers are used for which type of anginal attack

Classic

37

MOA of Cardiac glycosides (eg. digoxin)

Indirectly increase intracellular calcium and cardiac contractility by inhibit Na+/K+ ATPase

38

Digoxin is used in

Atrial fibrillation and CHF

39

Digoxin toxicity can be precipitated by

Hypokalemia

40

Antidote for digoxin toxicity

Digibind

41

Phosphodiesterase inhibitors that increase mortality and have been found to have NO beneficial effects

Amrinone and milrinone

42

SE of amrinone

Thrombocytopenia

43

Beta 1 agonists used in acute CHF

Dobutamine and dopamine

44

Diuretics work in CHF by

Reducing preload

45

Beta blockers work in CHF by

Reducing progression of heart failure (never use in acute heart failure)

46

Agent used in CHF that is a selective alpha and nonselective beta blocker

Carvedilol

47

Agent used in acutely decompensated CHF resembling natriuretic peptide

Nesiritide (Natrecor)