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Flashcards in PHARM NSAIDS.GOUT Deck (32):
1

MOA of NSAIDS

inhibit prostaglandin synthesis by inhibiting cyclo-oxygenase (cox)

2

Difference between aspirin and other NSAIDS

Aspirin irreversibly inhibits cyclooxygenase

3

Four main actions of NSAIDS

Anti-inflammatory, analgesia, antipyretic and antiplatelet activity

4

Agent used for closure of patent ductus arteriosus

Indomethacin

5

The reason why aspirin is contraindicated in children with viral infection

Potential for development of Reye's syndrome

6

SE of salicylates

Tinnitus, GI bleeding

7

NSAID available orally, IM, IV, nasally, and ophthalmically

Ketoralac

8

NSAID that is used for acute condition, such as pre-op anesthesia and has limited duration (<5 days) of use due to nephrotoxicity

Ketoralac

9

Newer NSAIDs that selectively inhibit COX-2

Celecoxib

10

COX 2 inhibitors may have reduced risk of

Gastric ulcers and GI Bleeding

11

COX 2 inhibitors should be used cautiously in pts with

Pre-existing cardiac or renal disease

12

Acetaminophen only has what activity?

Antipyretic and analgesic activity

13

SE of acetaminophen

Hepatotoxicity

14

Antidote for acetaminophen toxicity

N-acetylcysteine

15

DMARDs are slow acting drugs for

Rheumatic disease

16

MOA of gold salts

Alter activity of macrophages and suppress phagocytic activity of PMNs

17

SE of gold salts

Dermatitis of the mouth aplastic anemia and agranulocytosis

18

Causes bone marrow suppression

Methotrexate

19

SE of penicillamine

Aplastic anemia and renal

20

Interferes with activity of T-lymphocytes

Hydroxychloroquine

21

Anti-malarial drug used in rheumatoid arthritis (RA)

Hydroxychloroquine

22

SE of hydroxychloroquine

Retinal destruction and dermatitis

23

MOA of Leflunomide (newer agent)

Inhibiting Dihydroorotate Dehydrogenase which leads to decreased pyrimidine synthesis

24

Proteins that prevent action of tumor necrosis factor alpha (TNF-alpha)

Infliximab and etanercept

25

Anti-rheumatic agent also used for ulcerative colitis

Sulfasalazine

26

NSAID used in gout

Indomethacin, ibuprofen

27

NSAID avoided in gout because low doses increases uric acid levels

Aspirin

28

MOA of Colchicine (used in acute gout)

Selective inhibitor of microtubule assembly

29

SE of colchicine

Kidney and liver toxicity, diarrhea, myelosuppression

30

Agent used to treat chronic gout by increasing uric acid excretion through inhibition of URAT1 anion transporter

Probenecid

31

Agent that inhibits xanthine oxidases and used to treat chronic gout

Allopurinol, febuxostat

32

Recombinant uricases that enhance uric acid metabolism

rasburicase, pegloticase