Bone: Anatomy, Formation, Growth Plate Disorders, Maturation Disorders Flashcards Preview

Pathology Unit 5 > Bone: Anatomy, Formation, Growth Plate Disorders, Maturation Disorders > Flashcards

Flashcards in Bone: Anatomy, Formation, Growth Plate Disorders, Maturation Disorders Deck (30):
1

Significance of gray/ white marrow?

Pathologic, fibrotic tissue!

2

Difference between haverisan canals and volkmann canals?

Haversian= parallel to the long axis of the bone

volkmann canals= perpendicular to the long axis of the bone

3

What is organic bone matrix made of?

Type I collagen

4

What cells produce osteoid?

osteoblasts

5

What is the mineralization lag time?

12 days between when osteoid is deposited and it is mineralized

6

What can inhibit osteoclastic activity?

calcitonin

7

What is the "bone remodelling unit"?

Osteoblast and osteoclast

8

Which bone is more rapid and less arranged...lamellar or woven?

woven

9

What is the structure of the growth plate?

5 zones!

Reserve/ resting zone

Proliferative zone

Hypertrophic zone

Zone of calcification

Zone of ossification

10

What is morquio syndrome?

mucoplysaccharide deposition in chondricytes tha leads to dwarffism , dental defects and mental retardation

11

What is found in the urine of someone with morquio syndrome?

Keratin sulfate

12

What condition results from a vitamin C deficiency?

Scurvy

it is a problem with collagen cross linking and osteoblastic function leading to impaired bone growth

13

abnormal lateral curvature of the spine?

scoliosis

14

abnormal anteroposterior curvature of the spine?

kyphosis

15

One limb's growth plate is stimulated to undergo rapid and prolonged endochorndial ossification (one limb is longer)?

Hemihypertrophy

16

Erhlenmeyer flask deformity is associated with...

osteopetrosis

17

Which is the mildest phenotype of OI?

Type I

18

Which form of OI is usually fatal in utero or at birth?

Type II

19

Which is the progressive, most severely deforming OI?

Type III

20

What is the difference between type I and type IV OI?

Type IV has normal sclera (not blue)

21

What us endrochromatosis?

tumor like masses of abnormally arranged hyaline cartilage

22

What is Muffacci Syndrome?

Multiple enchondromas and cavernnous/ spindle cell hemangiomas

23

What day after a fracture is hemorrhage and clot formation seen?

day 2-5

24

What day after a fracture is earliest new bone seen?

day 7

25

Reparative phase has _______ ossification.

endochondrial

26

What is psuedoarthrosis?

formation of joint like tissue due to continued movement at a nonunion fracture site

27

What is Legg- Calve- Perthes disease?

osteonecrosis in the femoral head of children

28

What is fibrodysplasia ossificans?

massive deposits of bone around many joints

29

Difference between heterotropic ossification and heterotropic calcification?

bone deposition vs calcium deposition outside of the skeleton

30

What is myositis ossificans?

formation of reactive bone in muscle after injury