Endocrine: Parathyroid Flashcards Preview

Pathology Unit 5 > Endocrine: Parathyroid > Flashcards

Flashcards in Endocrine: Parathyroid Deck (20):
1

What is the the embryology of the parathyroid glands?

Branchial clefts III and IV

2

"parathyroid glands that secrete PTH"

Chief cells

3

Chief cells are (+) for...

Cromagranin A (+)

Synaptophysin (+)

4

What has negative feed back to PTH release?

Mg and Ca

5

Most common cause of hypoPTH?

surgical removal of parathyroids at time of a thyroidectomy

6

"tingling hands/ feet, convulsions, neuropsych disturbances, papilledema"

Hypoparathyroidism

7

"agenesis of the parathyroid" in the context of syndrome

DiGeorge syndrome

8

"short stature, obesity, mental retardation, subcutanous calcificans, insensitivity to PTH, TSH, glucacon, FSH, and LH"

Albright Hereditary osteodystrophy

9

What is the mutation in albright hereditary osteodystrophy?

GNAS1 mutation--> decreased cAMP

renal tubules cannot respond to PTH

10

Albright hereditary osteodystrophy is a form of....

psuedohypothyroidism or psuedo-psuedohypothyroidism

11

"hypercalcemia + hypophosphatemia + nephrolithiasis + bone disease"

hyperparathyroidism

12

Most common cause of hyperparathyroidisim?

parathyroid adenoma

13

"adipose tissue of the gand is replaced by hyperplastic chief cells and scattered oxyphil cells"

primary parathyroid hyperplasia

14

Which exposures can cause parathyroid hyperplasia?

Lithium and radiation

15

Are parathyroid carcinomas normally non functioning or functioning?

Usually functioning

16

Most common cause of death in parathyroid carcinoma?

Hyperparathyrodisim (not mets)

17

Skeletal finding in hyperparathyroidism?

Osteitis fibrosa cystica

18

Common symptoms of hyperparathyroidism?

ulcers, bone pain, hypercalcemia, hypophosphatemia, muscle wasting, kidney stones, emotional disorders, nasuea, vomiting, fatigue

19

Primary cause of secondary hyperparathyroidism?

Chronic renal failure

20

"autonomous parathyroid hyperplasia that develops after prolonged hyperplasia secondary to renal failure"

Tertiary Hyperparathyroidism