Flashcards in Endocrine: Pituitary Gland, Thyroid Gland Deck (24):
"AR form of short stature due to extreme resistance to GH because abnormalities in GH receptor"
"hypogonadic hypogonadism due to GnRH deficiency and anosmia, cleft lip/ palate)
Kallmann Syndrome (isolated gonadotropin deficiency)
"hereditary predisposition to pituitary adeonoma, parathyroid hyperplasia or adenoma, pancreatic islet cell adenoma"
MEN I mutation
What will Parafollicular C cells stain (+) for?
"complete absence of thyroid tissue, not uncovered until several weeks after birth"
"thyroid that is outside the normal area"
"thyroid tissue located lateral to the jugular veins or in lymph nodes and soft tissue adjacent to the thyroid glands"
lateral aberrant thyroid
Is a male or a female more likely to have a lingual thyroid?
female (found with difficulty swallowing, speaking or breathing)
"nests of thyroid tissue found anywhere along the path of its descent into the lower neck"
heterotropic thyroid tissue
"failed complete involution and cystic fluid filled remnant along the thyroglossal duct"
thyroglassal duct cyst
What are the two different histologic forms of nontoxic goiter?
Diffuse= early in disease
multinodular= late in disease/ chronic
What is myxedema?
boggy faces, puffy eyelids, edema of the hands and feet and enlarged tongue
What is thyroiditis?
inflammatory disorder of the thyroid
Histology seen in hashimotos?
Lymphocyte and plasma cell infiltrate
Hyrthle/ Askanazy cells--> follicular epithelial cells with oxyphilic metaplasia, filled with mitochondria and showing nuclear atypia
Histologic pattern of embryonal thyroid adenoma?
trabecular pattern with poorly formed follicles containing little of no colloid
Histologic pattern of fetal thyroid adenoma?
similar to embryonal adenoma but cells are arranged in microfollicles contaning little colloid
Histologic pattern of simple thyroid adenoma?
mature follicles with a normal amount of colloid
Histologic pattern of colloid thyroid adenoma?
simple adenoma but follicles are larger with more colloid
Histologic pattern of Hurthle (oncocytic) carcinoma?
Solid tumor with oxyphil cells, small follicles and scant colloid, become infarcted after needle aspiration biopsy
Most common thyroid cancer?
papillary thyroid cancer
What is diagnostic of papillary thyroid cancer?
Calcospherites (psammoma bodies)
What method does follicular thyroid carcinoma usually spread?
When do MEN type II B tumors occur?