Endocrine: Pituitary Gland, Thyroid Gland Flashcards Preview

Pathology Unit 5 > Endocrine: Pituitary Gland, Thyroid Gland > Flashcards

Flashcards in Endocrine: Pituitary Gland, Thyroid Gland Deck (24):
1

"AR form of short stature due to extreme resistance to GH because abnormalities in GH receptor"

Laron Syndrome

2

"hypogonadic hypogonadism due to GnRH deficiency and anosmia, cleft lip/ palate)

Kallmann Syndrome (isolated gonadotropin deficiency)

3

"hereditary predisposition to pituitary adeonoma, parathyroid hyperplasia or adenoma, pancreatic islet cell adenoma"

MEN I mutation

4

What will Parafollicular C cells stain (+) for?

chromogranin (+)

synaptophysin (+)

5

"complete absence of thyroid tissue, not uncovered until several weeks after birth"

thyroid agenesis

6

"thyroid that is outside the normal area"

ectopic thryoid

7

"thyroid tissue located lateral to the jugular veins or in lymph nodes and soft tissue adjacent to the thyroid glands"

lateral aberrant thyroid

8

Is a male or a female more likely to have a lingual thyroid?

female (found with difficulty swallowing, speaking or breathing)

9

"nests of thyroid tissue found anywhere along the path of its descent into the lower neck"

heterotropic thyroid tissue

10

"failed complete involution and cystic fluid filled remnant along the thyroglossal duct"

thyroglassal duct cyst

11

What are the two different histologic forms of nontoxic goiter?

Diffuse= early in disease

multinodular= late in disease/ chronic

12

What is myxedema?

boggy faces, puffy eyelids, edema of the hands and feet and enlarged tongue

13

What is thyroiditis?

inflammatory disorder of the thyroid

14

Histology seen in hashimotos?

Lymphocyte and plasma cell infiltrate

Hyrthle/ Askanazy cells--> follicular epithelial cells with oxyphilic metaplasia, filled with mitochondria and showing nuclear atypia

15

Histologic pattern of embryonal thyroid adenoma?

trabecular pattern with poorly formed follicles containing little of no colloid

16

Histologic pattern of fetal thyroid adenoma?

similar to embryonal adenoma but cells are arranged in microfollicles contaning little colloid

17

Histologic pattern of simple thyroid adenoma?

mature follicles with a normal amount of colloid

18

Histologic pattern of colloid thyroid adenoma?

simple adenoma but follicles are larger with more colloid

19

Histologic pattern of Hurthle (oncocytic) carcinoma?

Solid tumor with oxyphil cells, small follicles and scant colloid, become infarcted after needle aspiration biopsy

20

Most common thyroid cancer?

papillary thyroid cancer

21

What is diagnostic of papillary thyroid cancer?

Calcospherites (psammoma bodies)

22

What method does follicular thyroid carcinoma usually spread?

hematogenous

23

When do MEN type II B tumors occur?

Infancy

24

When do MEN type II A tumors occur?

Adolescence