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Flashcards in Breast Histology Deck (20)
1

How many lobes make up the secretory tissue of the breast?

15-25 lobes

2

What is each 'lobe' of the breast made up of

A tubule-acinar gland which drains via a series of ducts leading to the nipple

3

What is adjacent to the secretory lobule in the breast

dense fibrous tissue surrounded by fat tissue

4

Describe the duct system

Terminal ductules --> intralobular collecting duct ---> lactiferous duct--> lactiferous sinus-->nipple

5

What type of epithelium lines the larger ducts

columnar

6

What type of epithelium lines the secretory acini

cuboidal or low columnar

7

what epithelium covers the nipple

highly pigmented keratinized stratified squamous epithelium

8

What changes occur in the breast during the menstrual cycle

During the luteal phase the epithelial cells increase in height, the lumina of the ducts becomes enlarged and small amounts of secretions appear in the ducts.

9

What changes occur in the first trimester of pregnancy

In the first trimester there is elongation and branching of the smaller ducts, combined with proliferation of the epithelial cells of the glands and the myoepithelial cells.

10

What changes occur in the second trimester of pregnancy

In the second trimester glandular tissue continues to develop with differentiation of secretory alveoli. Also, plasma cells and lymphocytes infiltrate the nearby connective tissue.

11

What changes occur in the third trimester of pregnancy

In the third trimester secretory alveoli continue to mature, with development of extensive rER.

12

What are all changes in pregnancy accompanies by

reduction in the amount of connective tissue and adipose tissue present

13

What are the effects os oestrogen and progesterone during pregnancy on the breast

stimulate proliferation of secretory tissue and fibro-fatty tissue becomes sparse.

14

What is the consituients of breast milk

88% water
1.5% protein (mainly lactalbumin and casein)
7% carbohydrate (mainly lactose)
3.5% lipid

15

What immunoglobulin is present in breast milk

IgA

16

What happens to the breast tissue in menopause

the secretory cells of the TDLU’s degenerate leaving only ducts. In the connective tissue, there are fewer fibroblasts and reduced collagen and elastic fibres.

17

By what mechanism are lipids secreted in the breast

Apocrine secretion

18

Describe apocrine secretion

'budding off' of the fat droplets

19

By what mechanism is protein secreted in the breast to form breast milk

merocrine secretion

20

Describe merocrine secretion

Protein made in rER and packages in golgi apparatus and secreted in vesicles which merge with the apical membrane to release only their content into the duct system.