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Flashcards in HIV: Principles and Management Deck (10)
1

What is the treatment of rectal chlamydia

co-trimoxazole or doxycycline

2

What does reverse transcpitase do

turn the RNA molecules in HIV to DNA

3

What is the CCR5 receptor

chemokine co receptor - after the HIV virus binds to the T helper cell via the CD4 receptors this produces a conformational change and the HIV virus also binds to CCR5

4

what does integrase do

so once the RNA fo HIV has been changed to dDNA by reverse transcriptase - integrase grab hold of the DNA and takes it into the T helper cells nucleus - integrase allows the HIV to become integrated in to the host cell DNA

5

what

breaks up polyprotein chains allowing them to form functioning proteins and allow the new cell that is produced to become a new HIV cell which can go on to infect other T cells

6

What is HAART

a combination of three drugs from at least two drug classes which the virus is susceptible

7

what is the purpose of HAART

reduce viral load to undetectable
restore immunocompetence
reduce morbidity and mortality
minimise toxicity

8

Why is it important to be compliant to HIV medication

to prevent resistance

9

What are the side effects of HAART toxicity

GI side effects
skin rashes - stevens-johnsons
Mood problems, psychosis
renal toxicity
osteomalacia
increased MI risk
anaemia
fulminant hepatitis

10

How is transmission of HIV from mother to child prevented

HAART during pregnancy
vaginal deliverly if undetected viral load- c section if detected viral load
four weeks of Post exposure prophylaxis for neonate
do not breast feed