Breast Pathology Flashcards Preview

Hugh's MD2 Gen Med > Breast Pathology > Flashcards

Flashcards in Breast Pathology Deck (15):
1

How does fat necrosis present on examination?

Painless palpable mass

DDx for a malignant mass

2

What are some benign mimics of malignancy?

Radial scar

Sclerosing lesions

Fat necrosis

Microglandular adenosis

3

What type of gene is HER2?

Oncogene

4

What is ductal carcinoma in situ?

Epithelial neoplastic ductal cells that haven't crossed the basement membrane

No involvement of vessels or lymphatics

Presents as mass or calcification

Unable to metastasize

4

For what type of breast cancers is herceptin indicated?

HER2 positive

6

What is usual duct hyperplasia?

3 or more cells above the basement membrane

1.5-2RR for breast cancer in 15-20 years

7

What are the prognostic factor for breast Ca?

Size

Grade

Lymph node status

Completeness of excision

Oestrogen and progesterone receptor status

8

What determines the risk of recurrence with DCIS?

Size of DCIS

Grade

Pattern of growth

Presence of necrosis

Sentinal node

Surgical margins

Radiotherapy

8

What is more common, ductal or lobular carcinoma?

Ductal

10

What are some risk factors for breast Ca?

Age

First degree relative with breast cancer

Estrogen exposure HRT

Radiation exposure

Obesity

Age of menarche

Late menapause

First live birth

 

11

What is aypical ductal hyperplasia?

Almost like ductal carcinoma in situ

Requires increased surveilance

12

What are type of genes are BRCA1 and BRCA2? 

DNA repair genes

13

What is Mammary duct ectasia?

Generally non-painful

Causes ill defined, benign lumps

Can mimic more serious conditions

14

For what type of breast cancers is tamoxifen indicated?

ER+ and PR+ = Good response

ER+ and PR- = Low or intermediate response

ER- and PR- = poor response

15

What is periductal mastitis?

Idiopathic condition associated with smoking

Nipple ducts become blocked and painful maybe infected