Lung Pathology Flashcards Preview

Hugh's MD2 Gen Med > Lung Pathology > Flashcards

Flashcards in Lung Pathology Deck (26):
1

In what percentage of patients does progressive TB occur?

Less than 10% of all TB patients, usually immunosuppressed

1

What are some DDx of bilateral hilar enlargement?

Sarcoidosis

Lymphoma

TB

Metastasis

Other infections - fungal

1

What is honeycomb lung?

Irreversible end-stage manifestation of a large number of interstitial inflammatory and proliferative lung diseases

Poor prognosis

 

1

What is the pathogenesis of an exudate?

Altered permeability of or damage to the capillaries surrounding space

2

What are some non-infectious causes of pleuritis?

Trauma

Infarction

Connective tissue disorders: eg RA or lupus

Uraemia

Tumour

Radiation effect

2

What is a common cause of mesothelioma?

Asbestos

4

What is sarcoidosis?

Most common interstitial lung disease

5

What is a common first presentation of mesothelioma?

Pleural effusion

7

What type of TB typically occurs at the apex of the lung?

Secondary TB

9

What are common causes of interstitual lung disease?

Idiopathic 

Occupational/environmental exposure

Drugs

10

What is secondary TB?

Reactivation of a dormant focus of primary TB

or a new infection

11

What is the pathophysiology of mesothelioma?

Small fibres in the alveolar causes chronic stimulation > tumour develops

12

What is granulomatous inflammation?

Nodular clusters of macrophages +/- giant cells

12

What is the commonest cause of non-necrotising granulomas?

Sarcoidosis

13

What are differentials for granulomatous inflammation?

TB

Sarcoid

Lymphoma

14

What is Gohn's complex?

Gohn focus - TB lesion in the lung parenchyma

TB Lesion in a draining LN

16

What must you do before treating sarcoidosis?

Exclude infective causes as steroids will likely exacerbate the sarcoidosis

17

What is the prognosis of mesothelioma?

Average survival from onset of symptoms is 12-15 months

Mortality is 100%

18

What causes a chylous effusion?

High lymphocyte count - TB, lymphoma

20

How much fluid accumulation consitutes a pleural effusion?

>15mL

21

Typical presentation of interstitial lung disease?

Slow, increasing SOB

Dry cough

22

What is usual interstitial pneumonia?

Idiopathic pulmonary fibrosis

Cryptogenic fibrosing alveolitis

23

How do you differentiate adenocarcinoma with mesothelioma?

IHC staining

24

What is the difference between a transudate and exudate?

Transudate is lower in protein

25

What is the pattern of location of sarcoidosis?

Enlarged lymphadenopathy at the hilum

Bilateral granulomatous inflammation of lungs

26

What is the main differential for mesothelioma?

Adenocarcinoma