Breast Pathology I Flashcards Preview

REPRO II Exam 1 > Breast Pathology I > Flashcards

Flashcards in Breast Pathology I Deck (52):
1

TDLU

terminal ductal lobular unit
end of collecting duct in breast

function unit of breast

2

cell layers of breast

inner luminal cells
outer layer of myoepithelial basal cells
surrounding basal lamina layer

all surrounded by fat with arteries, veins, and lymph vessels

3

tanner scale

classification of pubertal breast

4

coopers ligaments

help breast stay elevated

constriction - dimpling

5

pectoralis fascia

forms deep margin of breast for surgery

6

expanding duct

bad sign

can form abscess and fissures to outside

7

lactiferous duct

enlarged and dilated near base of nipple - at lactiferous sinus

sinus - holds milk and discharges with smooth m contraction

cross section - scalloped - to allow expansion

8

most breast cancer

arise from TDLU

9

TDLU stroma

less dense

collagenous

10

S100

stains the myoepithelial cell protein

IPX stain

11

mammaglobin

breast secretion protein

12

luminal cells

secretory

13

myoepithelial cells

BM equivalent for invasion of cancer

S100 marker

14

young breast

harder to see on mammogram

15

ductal carcinoma

typically estrogen positive

16

basal carcinoma

typically estrogen negative

17

oxytocin

myoepithelial contraction - milk letdown

18

colostrum

earliest milk
-higher in protein and lower in lipids

19

supernumerary nipples

milk line remnants

20

older breasts

lobules decrease in size and number
interlobular stroma replaced by adipose

21

higher risk of lactiferous sinus obstruction

with inverted nipple

also difficulty breastfeeding

if congenital

22

acquired inverted nipple

must rule out underlying pathology - malignancy

23

painful breast cancer

only 10%

24

mastodynia

painful breast

aka mastalgia

25

bloody nipple discharge

must be investigated

26

galactorrhea

milky discharged associated with prolactin and meds

27

most presentation of breast cancer

abnormal mammogram

then palpable mass

some pain and nipple discharge

28

patient symptoms of breast cancer

most often - lumpiness or palpable mass

29

mammogram

sensitivity and specificity improve with age
-due to decreased density

see densities - to 1cm
microcalcifications

30

ultrasound of breast

differentiate cystic vs. solid

31

posterior shadow

on U/S of breast with solid lesion

32

malignant calcifications

small, irregular, clustered and numerous

commonest way to diagnose DCIS

33

diagnosis of palpable breast pass

cytology
biopsy - needle core, incisional, excisional
simultaneous staging (if malignant)

34

negative FNA rule out cancer

no

10% false negative rate

35

needle core biopsy

can determine if invasion has occured

can also do cytohisto marker studies

36

needle localization

to determine location of breast palpable mass

37

modified radical mastectomy

also removes axillary nodes

NOT pectoralis muscle

38

radical mastectomy

removes pectoralis muscle

39

lactational mastitis

acute mastitis - first month post partum (puerperal)

segmental with acute inflammation - 10% to abscess

start - nipple fissure and stasis - skin bacteria infection
-staph aureus and strep

40

non-lactational mastitis

periareolar - mammary duct ectasia
peripheral

41

mammary duct ectasia

obstructed lactiferous sinus at level of nipple
-with inverted nipple - and cigarette smoking

42

cigarette smoking

squamous metaplasia of lactiferous sinus - with keratin plugging

leads to non-lactational mastitis

43

periductal mastitis

with rupture

44

painful nursing

obstruction of breast duct

45

ectasis

dilation

46

ductogram

radio-opaque dye injected to sub-areolar sinus through openings of nipple

dye outlines duct architecture

47

trauma to breast

can lead to fat necrosis

48

fat necrosis

trauma to breast
-liquefactive necrosis of fat cells release cytoplasmic fat

acute foreign body granulomatous response - fibrosis repair

requires biopsy**

49

hard breast mass, dimpling of skin, following trauma

fat necrosis

50

breast implants

can induce fibrosis
-form constricting capsule - causes implant to rupture
-hard to determine cancer with implants

51

implants

no link to disease

52

atypical ductal hyperplasia

bridges form in ducts