Female Genital Pathology III Flashcards Preview

REPRO II Exam 1 > Female Genital Pathology III > Flashcards

Flashcards in Female Genital Pathology III Deck (27):
1

patterns of invasive SCC of vulva

60% - SCC, warty and bowenoid type (HPV) - repro age women

40% - SCC keratinizing type (no HPV) - elderly women 70yo

2

keratinizing SCC of vulva

no HPV
elderly women

3

warty SCC of vulva

yes HPV
women repro age

4

tx of SCC of vulva

vulvectomy and lymphadenectomy

5

prognosis - SCC of vulva

depends on stage

low - <1mm invasion - 80% 5 year

high - tumor invades sidewall, mets - 10% 5 year

6

keratin pearls

SCC - of vulva

7

any ulcerated lesion of vulva

needs biopsy

8

accesory breast tissue

along milk line
-extends into vulva

rarely - primary site of adenocarcinoma

9

sharply circumscribed nodule in vulva with normal overlying skin

papillary hidradenoma
-b9

double layer cells - columnar myoepithelial

10

paget disease

extramammary - malignant

itchy, red, crusty, sharply demarcated area on labia majora
-elderly women

11

cells of paget

germinal cells of mammary gland ducts in vulvar skin

12

halo cells

paget cells

13

PAS positive, mucin positive
CEA positive, EMA positive
S-100 negative, melanin-A negative

extramammary pagets

low potential for mets

14

tx of pagets

wide local excision

15

malignant melanoma

of vulva
-poor prognosis - usually nodular

S100 and melanin A positive

16

S100 positive
melanin A positive

malignant melanoma

17

pigmented lesion of vulva

needs to be biopsied**

melanosis - b9 pigmentation vs. melanoma - indistinguishable looking alone

18

most vaginal neoplasms

80% mets from cervix
SCC are most common primary cancer

arise from premalignant VaIN

HPV - esp 16

19

embryonal rhabdomyosarcoma

girls <3cm

lamina propria of vaginal wall

presentation - vaginal bleeding

20

cysts of lateral vaginal wall

gartner duct
-wolffian remnant


simple cyst with monolayer of b9 cuboidal epithelium

21

tx of gartner duct cyst

excisional bx

22

vaginal adenosis

normally - glandular epithelium - replaced by squamous epithelium - by 18 weeks

vaginal adenosis -doesn't occur

occured with DES use for miscarriages

23

DES

lead to vaginal adenosis

some affected daughters - clear cell carcinoma of vagina**

24

women with DES exposure in utero

increased risk of CIN and VIN

25

velvety red area on vaginal mucosa

vaginal adenosis

presence of glandular tissue in vagina - abnormal

26

grape like tumor

embryonal rhabdomyosarcoma

27

DES

adenosis > clear cell carcinoma