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What is the Jones Criteria?

Clinical and diagnostic criteria for rheumatic fever

5 major & 4 minor criteria and an absolute requirement (microbiologic or serologic) of recent GAS infection.

1

What are the jones major criteria for RF?

C arditis
A rthritis (migratory polyarthritis)
S (C) sydenham Chorea
E rythema Marginatum
S ubcutaneous nodule

2

What are the Jones minor criteria?

o Arthralgia (in the absence of polyarthritis as a major criterion)
o Fever (typically temperature of 102°F and occurring early in the course of illness)

LABORATORY
o Elevated acute-phase reactants (e.g., C-reactive protein, erythrocyte sedimentation rate)
o prolonged PR interval on electrocardiogram (1st degree heart block)

3

What is the Absolute Requirement for the diagnosis of RF?

Recent Group A Streptococcus Infection based on elevated or increasing serum antistreptococcal antibody titers


antistreptolysin O

4

What are the 3 circumstances in which the diagnosis of ARF can be made without strict adherence to the Jones criteria?

o Chorea as the only manifestation
o Indolent carditis may who 1st come to medical attention months after the onset of ARF.
o Finally, although most patients with recurrences of ARF fulfill the Jones criteria, some may not

5

What is the universal finding in rheumatic carditis?

Endocarditis (valvulitis)

6

Most common Valvular lesions in RF?

mitral valve> aortic valve> (right sided valves: tricuspid and pulmonic)

Heard as
o Mitral regurgitation: pitched apical holosystolic murmur radiating to the axilla
o Aortic insufficiency: high-pitched decrescendo diastolic murmur at the upper left sternal border

7

Treatment for RF

ANTIBIOTICS
o 10 days of orally administered penicillin or erythromycin or a single intramuscular injection of benzathine penicillin to eradicate GAS from the upper respiratory tract
o benzathine penicillin G (600,000 IU for children 60 lb and 1.2 million IU for those 60 lb) every 4 wk until the patient reaches 21 yr of age or until 5 yr have elapsed since the last rheumatic fever attack, whichever is longer.
o alternative: penVK or macrolide

ANTIINFLAMMATORY
o Aspirin dosage: 100 mg/kg/day in 4 divided doses PO for 3-5 days followed by 75 mg/kg/day in 4 divided doses PO for 4 wk
o Prednisone dosage: 2 mg/kg/day in 4 divided doses for 2-3 wk followed by a tapering of the dose that reduces the dose by 5 mg/24 hr every 2-3 days for cardiomegaly or CHF
o salicylates & corticosteroids should be withheld if arthralgia or atypical arthritis is the only clinical manifestation which may interfere with the development of the characteristic migratory polyarthritis
o paracetamol for pain relief

8

Treatment for Sydenham Chorea of RF

o Phenobarbital (16-32 mg every 6-8 hr PO) is the drug of choice

o If phenobarbital is ineffective, then haloperidol (0.01-0.03 mg/kg/24 hr divided bid PO) or

o Chlorpromazine (0.5 mg/kg every 4-6 hr PO) should be initiated

9

Most common valvular involvement in children with RHD

Mitral Insufficiency

10

Characteristic heart murmur in RHD with mild Mitral Insufficiency

high-pitched holosystolic murmur at the apex that radiates to the axilla

11

Most common valvular involvement in adults with RHD

Mitral Stenosis

-usually takes 10 yr or more for the lesion to become fully established

12

an apical presystolic murmur resembling that of mitral stenosis sometimes heard and is a result of the large regurgitant aortic flow in diastole preventing the mitral valve from opening fully in RHD with aortic insufficiency

Austin Flint murmur

13

murmur in pulmonary insufficiency secondary to RHD which is similar to that of aortic insufficiency, but with absent peripheral arterial signs (bounding pulses).

Graham Steell murmur

14

Define Sinus bradycardia in

A. Neonates
B. Older children

A. Neonates: HR <60

15

Treatment for PVC

Correct underlying cause
IV lidocaine
Amiodarone

-intravenous lidocaine bolus and drip is the 1st line of therapy, with more effective drugs such as amiodarone reserved for refractory cases or for patients underlying ventricular dysfunction or hemodynamic compromise.

16

most common type of shock in children worldwide, usually related to fluid losses from severe diarrhea

Hypovolemic shock

17

When hypovolemia occurs as a result of third spacing of intravascular fluids into the extravascular compartment, the shock is described as

Distributive Shock (sepsis and burn)

18

profound myocardial dysfunction as cause of shock

Cardiogenic shock (due to congenital heart disease, myocarditis, and cardiomyopathies)

19

occurs when cardiac output is lowered by obstruction of blood flow to the body, as occurs when a ductus arteriosus closes in a child with ductus-dependent systemic blood flow in pericardial tamponade, tension pneumothorax, or massive pulmonary embolism

Obstructive shock

20

factors known to cause bradycardia, referred to collectively as the 6Ts and 4Hs

6 Hs
hypoxia, hypovolemia, hydrogen ions [acidosis], hypokalemia or hyperkalemia, hypoglycemia, hypothermia

4 Ts
toxins, tamponade, tension pneumothorax, and trauma [causing hypovolemia, intracranial hypertension, cardiac compromise or tamponade]

21

Rescue breaths given to Infants and children ≤8 yr old

Infants and children ≤8 yr old should receive rescue breathing at a rate of roughly 15-20 breaths/min, or roughly 1 breath every 3-5 se

22

Rescue breaths given to Children >8 yr old

Children >8 yr old should receive 10-12 breaths/min, or 1 breath every 5-6 sec.

23

How to give chest compressions to <1yo

Chest compressions in infants <1 yr old may be performed by placing 2 thumbs on the midsternum with the hands encircling the thorax or by placing 2 fingers over the midsternum and compressing

24

How to do chest compressions in >1yo

For children >1 yr old, the care provider should perform chest compressions over the lower half of the sternum with the heel of 1 hand, or with 2 hands as used for adult resuscitation

25

What is universal ratio of chest compressions for a lone rescuer?

universal ratio of 30 compressions to 2 ventilations

26

most common form of cardiomyopathy and is characterized predominantly by left ventricular dilation and decreased left ventricular systolic function

Dilated Cardiomyopathy

27

Cardiomyopathy that demonstrates increased ventricular myocardial wall thickness, normal or increased systolic function, and often, diastolic (relaxation) abnormalities

Hypertrophic Cardiomyopathy

28

cardiomyopathy characterized by nearly normal ventricular chamber size and wall thickness with preserved systolic function, but dramatically impaired diastolic function leading to elevated filling pressures and atrial enlargement

Restrictive cardiomyopathy

29

Cardiomyopathy characterized by specific morphologic abnormalities and heterogeneous functional disturbances

Arrhythmogenic right ventricular cardiomyopathy and left ventricular non-compaction