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Flashcards in Cellular biochem Deck (22):
1

RER
- what protein modifications

N-linked oligosac addition

2

smooth ER function
- what cells rich in them

- steroid synthesis
- detox of drugs and poisons
- liver (for detox) and adrenal cortex/gonads (for hormones)

3

Golgi
- what protein modifications

- N-oligosac on asparagine
- O-oligosac on Ser and Thr
- adds M6P to proteins meant for lysosome

4

anterograde vesicular trafficking

COP-II (ER to golgi)

5

retrograde vesicular trafficking

COP-I (golgi to ER)

6

peroxisome function

catabolism of:
- very long chain FA's
- branched FAs

7

I-Cell disease
- what is it
- mechanism
- features

- inclusion cell disease
- inherited lysosomal storage d/o
- golgi doesn't do M6P
- coarse facial features, clouded corneas, restricted joint movement, high plasma levels of lyosomal enzymes

8

retrograde molecular motor protein

dynein (+ to -)

9

anterograde molecular motor protein

kinesin (- to +)

10

actin and myosin used for what?

muscle contraction
microvilli
cytokinesis
adherens junctions

11

intermediate filaments used for?

structural components:
vimentin, desmin, cytokeratin, lamins, glial fibrillary acid proteins (GFAP)

12

Vimentin immunohistological stains what?

Vimentin in connective tissue

13

Desmin immunohistological stains what?

Muscle

14

Cytokeratin immunohistological stains what

Epitheliail cells

15

GFAP immunohistological stains what?

neuroglia

16

collagen type I
- where?
- decreased production in what

bone, tendon, fascia, skin
dentin
cornea
late wound repair

decreased in osteogenesis imperfecta type I

17

collagen type Ii
where?

cartilage
vitreous body
nucleus pulposus

18

collagen type III where?
def in what ?

reticulin
skin
blood vessels
uterus
fetal tissue
granulation tissue

def in vascular Ehlers-Danlos syndrome

19

collagen type IV where?

basement MB
basal lamina
lens

20

Elastin rich in what aa's

proline and glycine

21

Fibrillin
- def in what

glycoprotein that forms sheath around elastin
- Marfan

22

in starvation situations, what does liver convert into glucose (3)

1. alanine
2. lactate
3. glycerol