FA Rapid Review: Class Labs/Findings Flashcards
1
Q
Anti-centromere
A
Scleroderma CREST
2
Q
Anti-desmoglein (epithelial)
A
Pemphigus vulgaris (blistering)
3
Q
Anti-GBM
A
Goodpasture syndrome (GN and hemoptysis)
4
Q
Anti-histone
A
drug-induced SLE
- Hydralazine
- INH
- Phenytoin
- Procainamide
5
Q
Anti-IgG
A
RA
- systemic inflammation
- joint pannus
- boutonniere deformity
6
Q
Anti-mitochondrial (AMA’s)
A
Primary biliary cirrhosis
- female, cholestasis, portal HTN
7
Q
p-ANCA/MPO-ANCA
A
Microscopic Polyangiitis
Churg-Strauss syndrome
8
Q
c-ANCA/PR3-ANCA
A
Granulomatosis with polyangiitis (Wegener granulomatosis
9
Q
Anti-platelet
A
SLE (type III hypersensitivity)
10
Q
Anti-topoisomerase
A
Diffuse systemic sclerosis
11
Q
Anti-transglutaminase/anti-gliadin/anti-endomysial
A
Celiac disease
- diarrhea
- distension
- wt loss
12
Q
“Apple core” lesion on abdominal x-ray
A
Colorectal cancer (usually left sided)
13
Q
Azurophilic peroxidase + granular inclusions in granlocytes and myeloblasts
A
Auer rods
- AML, esp promyelocytic [M3] type
14
Q
Bacitracin response
- what’s sensitive and what’s resistant
A
sensitive: strep pyogenes (group A)
resistant: strep agalactiae (group B)
15
Q
Bamboo spine on x-ray
- what marker
A
ankylosing spondylitis (HLA-B27)
16
Q
basophilic nuclear remnants in RBCs
2/2 what
A
howell-jolly bodies
- splenectomy or nonfuntional spleen
17
Q
basphilic stippling of RBCs (2)
A
- Pb poisoning
2. sideroblastic anemia
18
Q
boot shaped heart on x-ray (2)
A
Tet
RVH
19
Q
branching gram positive rods with sulfur granules
A
actinomyces israelii
20
Q
bronchogenic apical lung tumor on imaging
A
pancoast tumor
21
Q
brown tumor of bone (2)
- why brown
A
- hyperparathyroidism
- osteitis fibrosa cystica
- deposited hemosiderin from hemorrhage
22
Q
cardiomegaly with apical
A
Chagas dz 2/2 Trypanosoma cruzi
23
Q
cellular crescents in Bowman capsule
A
rapidly progressive crescentic glomerulonephritis
24
Q
chocolate cyst of ovary
A
endometriosis
25
circular grouping of dark tumor cells surrounding pale neurofibrils
- seen in what conditions (3)
Homer-Wright rosettes
- neuroblastoma
- medulloblastoma
- retinoblastoma
26
colonies of mucoid pseudomonas in lungs with which condition
CF
27
decrease AFP in amniotic fluid and maternal serum
down
28
degeneration of dorsal columns
tabes dorsalis with teritary syphillis
29
depigmentation of neurons in substantia nigra with what condition
PD
30
desquamated epithlium casts in sputum called what
| - in what condition
Curschmann spirals
bronchial asthma
31
disarrayed granulosa cells in eosinophilic fluid called what?
- in what condition
- Call-Exner bodies
| - granulosa-theca cell tumor of ovary
32
dysplastic squamous cervical cells with nuclear enlargement and hyperchromosasia called what
- seen in what
koilocytes
HOV
33
enlarged cells with intranuclear inclusion bodies called what
- seen in what condition
Owl eyes
CMV
34
enlarged thyroid cells w/ground-glass nuclei called what? seen in what?
- Orphan Annie eyes nuclei
| - papillary carcinoma of thyroid
35
eosinophilic cytoplasmic inclusion in liver cell called what
- seen in what
Mallory body
| - alcoholic liver disease
36
eosinophilic cytoplasmic inclusion in nerve cell called what
- seen in what
Lewy body
- PD
37
eosinophilic globule in liver called what
- seen in what
councilman body
- toxic or viral hepatitis
38
eosinophilic inclusion bodies in cytoplasm of hippocampal and cerebellar nerve cells called what
- seen in what
negri bodies
rabies
39
extracellular amyloid deposition in gray matter of brain called what
seen in what
senile plauqes
AD
40
Giant B cells with bilobed nuclei with prominent Owl Eye inclusions called what
- seen in what
Reed-Sternberg cells
Hodgkin lymphoma
41
Glomerlus-like structure surrounding vessel in germ cells called what
- seen in what
Schiller-Duval bodies
- yolk sac tumor
42
hair on end appearance on x-ray in what condition (2)
- due to what
beta-thalassemia
sickle cell anemia
BM expansion
43
hCG elevated in what conditions (2)
choriocarcinoma
hydatidform mole
44
granulomatous heart nodules called what
seen in what
Aschoff bodies
rheumatic fever
45
heterophilic antibodies seen in what
infectious mono (EBV)
46
heaxagonal, double-pointed, needle-like crystals in bronchial secretions called what?
seen in what
charcot-leyden crystals
w/ eosinophilic granules
bronchial asthma
47
high level of d-dimers in what conditions (3)
DVT
PE
DIC
48
hilar LAD, peripheral granulomatous lesion in middle of lower lung lobes called what
- seen in what
Ghon complex
primary TB
49
honeycomb lung on x-ray or CT seen in what condition
IPF
50
Trousseau syndrome
- what is it
- a/w what condition
hypercoagulable state
a/w adenocarcinoma of pancreas or lung
51
hypersegmented neutrophils
seen in what
caused by what
megaloblastic anemia
b12 def
52
Conn syndrome (3)
1. HTN
2. hypo-K
3. metabolic alkalosis
53
where you see hypochromic, microcytic anemia (3)
1. fe def
2. pb poisoning
3. thalassemia
54
when do you see increased AFP in amniotic fluid (3)
1. dating error
2. anencephaly
3. spina bifida and other neural tube def
55
when do you see increased uric acid levels (4)
1. gout
2. lesch-nyhan syndrome
3. tumor lysis syndrome
4. loop and thiazide diuretics
56
intranuclear eosinophilic droplet-like bodies are called what
seen in what
Cowdry type A bodies
- HSV or CMV
57
iron-containing nodules in alveolar sputum called what
seen in what
ferruginous bodies
asbestosis
58
feratin pearls seen on skin bx in what condition
squamous cell carcinoma
59
large lysosomal vesicles in phagocytes with immunodeficiency ... what condition
Chediak-Higashi disease (congenital failure of phagolysosome formation)
60
"lead pipe" appearance of colon on barium enema x-ray seen in what condition
- why?
ulcerative colitis
| - loss of haustra
61
linear appearance of IgG deposition on glomerular basement MB in what condition
goodpasture
62
low serum ceruloplasmin in what condition
wilson disease
63
lumpy bumpy appearance of glomeruli on immunofluorescence in what condition
due to what
poststrep glomerulonephritis
immune complex deposition of IgG and C3b
64
lytic bone lesions on x-ray in what condition
multiple myeloma
65
blue domed cyst of mammary gland is called what
fibrocystic change of breast
66
monoclonal antibody spike seen in what conditiosn (4)
1. multiple myeloma (IgG or igA)
2. MGUS
3. Waldenstrom (IgM)
4. Primary amyloidosis
67
mucin-filled cell with peripheral nucleus called what
- seen in what
signet ring
gastric carcinoma
68
narrowing of bowel lumen on barium x-ray called what
seen in what
string sign
crohn disease
69
necrotizing vasculitis (lungs0 and necrotizing glomerulonephritis seen in what condition (2)
- what markers
1. granulomatosis w/polyangitiis (Wegener) - PR3-ANCA/c-ANCA
| 2. goodpsature - anti-basement MB
70
needle-shaped, negatively bifringent crystals called what
seen in what
monosodium urate cystals
gout
71
nodular hyaline deposits in glomeruli called what
seen in what
Kimmelstiel-Wilson nodules
diabetic nephropathy
72
Novobiocin response
- sensitive to what
- resistant what
sensitive: staph epidermidis
resistant: staph saprophyticus
73
nutmeg apperance of liver seen in what
chronic passive congestion of liver 2/2 Right heart failure
74
onion skin periosteal reaction seen in what
Ewing sarcoma
75
optochin response
- sensitive to what
- resistance to what
sensitive: strep pneumo
resistant: viridans strep
76
periosteum raised from bone, creating triangular area on x-ray called what
seen in what (3)
Codman triangle
- osteosarcome
- Ewing sarcoma
- Pyogenic osteomyelitis
77
podocyte effacement on EM seen in what contidion
MCD
78
polised, ivory like appearance of bone at cartilage erosion called what
seen in what
eburnation
osteoarthritis resulting in bony sclerosis
79
protein aggregates in neurons from hyper-phosphoryaltion of tau proteins --> called what
seen in what
neurofibrillary tangles
AD
80
psammoma bodies seen in what (5)
1. meningioma
2. papillary thyroid carcinoma
3. mesothelioma
4. papillary serous carcnioma of endometrium
5. papillary serous carcinoma of ovary
81
pseudopalisaing tumor cells on brain bx in what condition
glioblastoma multiforme
82
RBC casts in urine in what condition
acute glomerulonephritis
83
rectangular, crystal-like cytoplasmic inclusions in Leydig cells called what
seen in what
Reinke crystals
-Leydig cell tumor
84
renal epithelial casts in urine seen in what condition
acute toxic/viral renal injury
85
rhomboid crystals with positive birefringent seen in what condition
- what are they
pseudogout
calcium pyrophosphate dihydrate crystals
86
rib notching seen in what condition
coarcation of aorta
87
ring-enhancing brain lesions in AIDS pts (2)
toxo
or
CNS lymphoma
88
sheets of medium sized lymphoid cells w/scattered pale tingible body-laden macrophages
"starry sky" histology seen in what
```
burkitt lymphoma (t(8;14) c-myc activation)
EBV
```
starry night are stars of malignant cells
89
silver-staining spherical aggregation of tau proteins in neurons called what
pick bodies
90
soap bubble femor or tibia on x-ray from what
giant cell tumor of bone
91
spikes on basement MBwith "dome-like" subepithelial deposits seen in what
membranous glomerulonephritis
92
stacks of RBCs called what
seen in what (2)
rouleaux formation
1. high ESR
2. MM
93
stippled vaginal epithelial cells called what
seen in what
Clue cells
gardnerella vaginalis
94
tennis racket-shpaed cytoplasmic organelles (EM) in Langerhans cells are called what
seen in what
Birbeck granules
eosinophilic granuloma (Langerhans histiocytosis X)
95
thrombi made of white/red layers called what
seen in what
Lines of Zahn
arterial thrombosis
96
thumb sign on lateral x-ray seen in what
epiglottitis caused by h flu
97
thyroid-like apperance of kidney caused by what
chronic bacterial pyelonephritis
98
tram-track appearance of capillary loops of glomerular basement BM on light micro
membranoproliferative glomerulonephritis
99
TG accumulation in liver cell vacuoles in what condition
fatty liver disease
| alcoholic or metabolic
100
waxy casts w/very low urine flow seen in what
chronic ESRD
101
WBC casts in urine seen in what
acute pyelonephritis
102
WBCs that look smudged in what condition
CLL (almost always B cells)
103
wire loop glomerular capillary apperance on light micro in what condition
lupus nephropathy
104
yellowish CSF is called what
- seen in what
xanthochromia
SAH
