Vitamins biochem Flashcards Preview

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Flashcards in Vitamins biochem Deck (12):
1

Vit A

used to treat meales and AML
essential for normal differentiation of epithelial cells into specialized tissue

2

B1

thiamine

ATP
1. Alpha ketoglutarate dehydrogenase (TCA cycle)
2. Transketolase (HMP shunt)
3. Pyruvate dehydrogenase (glycolysis to TCA)

Wernicke-korsakoff, and beriberi's

3

B2

- needed for what
- def --> ?

Riboflavin

- needed for FAD and FMN; for redox rxns
- 2C'2 of B2: cheilosis (inflammation of lips and corners of mouth) + Corneal vascularization

4

B3

needed for what
derived from what
def --> ?
excess -->?

niacin

- NAD+ NADP+ for redox
- from tryptophan using B2 and B6
- 3D's of B3: dermatitis, diarrhea, dementia
- PG induced flushing, hyperglycemia, hyperuricemia

5

B6

needed for what
def --> ?

pyridoxine

- needed for transmination, glycogen phosphorylase, heme synthesis, NT synthesis
- convulsions, peripheral neuropathy, sideroblastic anemia b/c impaired Hb synthesis

6

B5

needed for?
def --> ?

Pantothenate (pentothenate for 5)

needed for CoA and FA synthase
dermatitis, enteritis, alopecia, adrenal insufficiency

7

B7

- needed for?
def --> ?

biotin

carboxylations
- pyruvate carboxylase (pyruvate (3) --> OAA (4))
acetyl-CoA coarboxylase (acetyl-CoA (2) --> malonyl-CoA (3))
- propionyl-CoA carboxylase (propionyl-Coa (3) --> methylmalonyl-CoA (4)

- def --> dermatitis, alopecia, enteritis

8

B9

needed for
def -->

THF, which is necessary for methylation reactions
important for synthesis of nitrogenous bases in DNA and RNA

- megaloblastic anemia, glossitis
elevated homocysteine but not MMA

seen in alcoholism

9

B12

needed for
def -->

cobalamin

- cofactor for homocysteine methyltransferase
- needed for myelin stability

- neuro issues
MMA and homocysteine

10

Vit E
function
def?

antiooxidant that protects RBC MB's from free radical damage

hemolytic anemia, acanthocytosis, muscle weakness, posterior and spinocerebellar tract demyelination

11

Marasmus
- what is it
- leads to?

total calorie malnutrition
muscle wasting and variable edema

12

Zinc def
- presentation (7)

1. vesicular/pustular erythematous skin lesions around orifices
2. hypogonadism
3. azospermia
4. hair loss
5. imparied taste
6. night blindness
7. impaired wound healing