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Flashcards in Cervical Dysplasia Deck (10)
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1

What are the histological gradings of cervical dysplasia?

HPV, CIN 1 - 3

2

What are the cytological gradings of cervical dysplasia? and how do they correlate to the histological grading

low grade squamous intraepithelial lesion (HPV+CIN1)

High grade, corresponding to CIN2 and 3

3

Which strain of HPV accounts for most of the dysplasia cases

HPV 16 and 18

4

Which age group is at the highest risk for HPV infection

20-24

5

HPV has early and late genes. What do the late genes encode? What do the early genes encode?

late - capsule proteins
early - proliferative proteins

6

T/F The cervical epithelium needs to be damaged before HPV can cause damage

True

7

Three important proteins are important in HPV infection. What are they and what are their functions

E2 - suppress E6 and E7

when inhibition is lifted (E2 incorporated into host genome)

E6 - suppress p53
E7 - suppress retinoblastoma gene

8

Which zone in the cervix is most prone to HPV infection

Transitional zone

9

Can we get glandular dysplasia in the cervix

No, only adenocarcinoma in situ

10

How are CIN1, 2, 3 differentiated

There are three layers above the basal lamina on transitional zone
CIN1 - only affects the basal layer
CIN2- affecting middle layer
CIN3- affecting the entire thickness